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Cat. No.: HY-W722277A

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LCC-12 formate

Name: LCC-12 formate
Brand: MedChemExpress
SKU: HY-W722277A
Price: 117.00 USD
Availability: InStock
Rating: 5 (1 reviews)

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LCC-12 formate is a mitochondria-targeted Copper²⁺-selective binder and metabolic/epigenetic reprogramming agent. LCC-12 formate inhibits NAD (H) redox cycling and reduces the NAD (H) pool. LCC-12 formate downregulates the expression of inflammatory genes and improves outcomes in mouse models of bacterial sepsis, endotoxemia, and SARS-CoV-2 infection. LCC-12 formate can be used in research related to acute inflammation, endotoxemia, sepsis, and SARS-CoV-2 infection.

For research use only. We do not sell to patients.

Purity : 99.90%
Formula: C₁₇H₃₈N₁₀O₂
Molecular Weight:414.55

Storage:

-20°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

LCC-12 formate Chemical Structure

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Top Publications Citing

Use of MCE Products

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Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
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Classifications
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Biological Activity

Description

In Vitro

Mitochondrial FunctionCarbohydrate MetabolismOthersInnate ImmunityCytokines & ChemokinesAdaptive ImmunityAnti-cancer

Mitochondrial Function

Carbohydrate Metabolism

LCC-12 (10 μM) formate reduces the levels of mitochondrial NAD⁺ and NADH pools in primary activated monocyte-derived macrophages (aMDM)^[1].

Others

LCC-12 formate selectively forms a stable monometallic complex with copper (II) in a cell-free system, while it shows no significant binding to most other divalent metal ions or copper (I)^[2].
LCC-12 formate inhibits copper (II)-catalyzed redox cycling of NADH to NAD⁺ in a dose-dependent manner in a cell-free system mimicking the mitochondrial matrix^[2].

Innate Immunity

Cytokines & Chemokines

LCC-12 formate induces epigenetic reprogramming in activated monocyte-derived macrophages, increases histone methylation levels, decreases histone acetylation levels, and downregulates pro-inflammatory gene expression and cytokine secretion^[2].

Innate Immunity

Adaptive Immunity

LCC-12 formate inhibits the activation of immune cells with upregulated CD44, and exerts effects on CD44-related copper-dependent cellular plasticity^[2].

Innate Immunity

Anti-cancer

LCC-12 formate potently interferes with the activation of monocyte-derived macrophages and inhibits CD44-associated epithelial-mesenchymal transition in cancer cells^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Innate ImmunityCytokines & ChemokinesViral InfectionOthers

Innate Immunity

Cytokines & Chemokines

Viral Infection

LCC-12 (inhalation) formate regulates chromatin and inflammatory gene expression in alveolar macrophages of K18-hACE2 mice infected with SARS-CoV-2^[1].

Others

LCC-12 (i.p.) formate protects mice against LPS-induced death and prevents hypothermia^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Chemical Information

Appearance Solid
Molecular Weight 414.55
Formula C₁₇H₃₈N₁₀O₂
Color White to off-white
SMILES

NC(NC(NCCCCCCCCCCCCNC(NC(N)=N)=N)=N)=N.O=CO
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Solier S, et al. A druggable copper-signalling pathway that drives inflammation. Nature. 2023 May;617(7960):386-394. [Content Brief]

[2]. Solier S, et al. Discovery of a druggable copper-signaling pathway that drives cell plasticity and inflammation[J]. bioRxiv, 2022: 2022.03. 29.486253.

[3]. Weiskirchen R. Targeting copper to combat macrophage-driven inflammation: a potential advanced therapeutic strategy. Signal Transduct Target Ther. 2023 Sep 11;8(1):339. [Content Brief]

[4]. Flemming A, et al. Copper boosts pro-inflammatory state of macrophages. Nature reviews. Immunology. 2023 Jun;23(6):344. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
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- In Vivo
Chemical Information
Purity & Documentation
References

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LCC-12 formate

Biological Activity

Description

In Vitro

In Vivo

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

LCC-12 formate Related Classifications

HY-W722277A Related Classifications

Bioz

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