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Cat. No.: HY-112335

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Lck Inhibitor III

Lck Inhibitor III is a Lck inhibitor with an IC₅₀ of 867 nM. Lck Inhibitor III inhibits the production of interleukin-2 (IL-2). Lck Inhibitor III can be used in the study of autoimmune diseases.

For research use only. We do not sell to patients.

CAS No.: 1188890-30-3
Formula: C₂₅H₃₀N₆O₄
Molecular Weight:478.54

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (281 KB)

Lck Inhibitor III Chemical Structure

CAS No.: 1188890-30-3

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

HY-13942
1-NM-PP1

Src Inhibitor

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

Lck

867 nM (IC₅₀)

IL-2

1.270 μM (IC₅₀)

All Src Isoforms :

All Interleukin Related Isoforms :

In Vitro

Cytokines & ChemokinesOthers

Cytokines & Chemokines

Lck Inhibitor III 可抑制 Jurkat 细胞中 IL-2 的产生，其 IC₅₀ 为 1.270 μM^[1]。

Others

Lck Inhibitor III (Compound 12h) 可抑制纯化的淋巴细胞特异性激酶 (Lck)，其 IC₅₀ 为 867 nM^[1]。
Lck Inhibitor III (1 μM; 1 h) 在冷冻保存的大鼠肝细胞悬液中的固有清除率为 48 mL/min kg^[1]。

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1188890-30-3
Molecular Weight 478.54
Formula C₂₅H₃₀N₆O₄
SMILES

CC1=CC=C(C=C1NC2=NC(N3C4=CC=CC=C4N=C3)=NC(OCCN5CCOCC5)=C2)OC.O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (281 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Sabat M, et al. The development of 2-benzimidazole substituted pyrimidine based inhibitors of lymphocyte specific kinase (Lck). Bioorganic & medicinal chemistry letters. 2006 Dec 01;16(23):5973-7. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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MOQ

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100 mg

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