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Cat. No.: HY-187584

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LQZ-7

LQZ-7 is a survivin inhibitor and molecular glue degrader (K_d=0.24 μM). LQZ-7 binds to the dimerization interface of survivin, disrupting homodimerization and dissociating dimeric survivin into monomers, thereby accelerating its proteasome-dependent degradation. LQZ-7 does not affect the structurally similar dimeric proteins 14-3-3σ and 14-3-3δ, and can induce apoptosis, exhibiting cytotoxicity against cancer cells.

For research use only. We do not sell to patients.

CAS No.: 1044664-73-4
Formula: C₂₄H₁₉N₇O₄
Molecular Weight:469.45

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

LQZ-7 Chemical Structure

CAS No.: 1044664-73-4

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
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Biological Activity

Description

Cellular Effect

Cell Line	Type	Value	Description	References
PC-3	IC50	25 μM	Inhibitory concentration 50% against human PC-3 cancer cells assessed as reduction in cell survival incubated for 3 days by MTT assay. Inhibitory concentration 50% against human PC-3 cancer cells assessed as reduction in cell survival incubated for 3 days by MTT assay.	26744521
DU-145	IC50	25 μM	Inhibitory concentration 50% against human DU145 cancer cells assessed as reduction in cell survival incubated for 3 days by MTT assay. Inhibitory concentration 50% against human DU145 cancer cells assessed as reduction in cell survival incubated for 3 days by MTT assay.	26744521

In Vitro

Bacterial InfectionAnti-cancerApoptosis

Bacterial Infection

LQZ-7 (30 min) dissociates existing dimeric survivin^[1].
LQZ-7 (25 µM; 3 days) inhibits survival of PC-3 and DU145 cells with an IC₅₀ of ~25 µM^[1].

Anti-cancer

LQZ-7 (10 µM; 24 hours) induced survivin loss in PC-3 cells is reversed by proteasome inhibitors^[1].
LQZ-7 induces proteasome-dependent degradation of survivin in cancer cells^[2].

Apoptosis

Anti-cancer

LQZ-7 (20 μM) binds to survivin, disrupts survivin dimerization, and accelerates proteasome-dependent degradation of survivin, exhibiting cytotoxicity against Du145 and PC3 cells with an IC₅₀ of ~25 μM^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

DU145 and PC-3
Concentration:

25 µM
Incubation Time:

3 days
Result:

Inhibited survival of human PC-3 and DU145 cells with an IC50 of ~25 µM.

Western Blot Analysis^[1]

Cell Line:

PC-3
Concentration:

10 µM
Incubation Time:

24 hours
Result:

Induced survivin loss that was reversed by co-treatment with a proteasome inhibitor, MG132 or bortezomib.

In Vivo

Anti-cancer

LQZ-7F (25 mg/kg; i.p.; every 3 days; 8 doses) effectively inhibits the growth of PC-3 xenograft tumors in vivo by inducing apoptosis and reducing survivin levels^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

NOD/SCID (male, 4-6 weeks old)^[1]
Dosage:

25 mg/kg
Administration:

i.p.; every 3 days; 8 doses
Result:

Inhibited the growth of PC-3 xenograft tumors compared to the vehicle control.
Reduced final average tumor weight significantly compared to the control group.
Maintained constant body weight after multiple dosings.
Induced apoptosis, showing more apoptotic cells with condensed chromatin.
Dramatically reduced survivin levels as determined by Western blot and immunohistochemistry.

Related Protocols :

Chemical Information

CAS No. 1044664-73-4
Molecular Weight 469.45
Formula C₂₄H₁₉N₇O₄
SMILES

OC(C1=CC=CC(C2=CC=C(O2)/C=N/NC3=NC4=NON=C4N=C3NC5=C(C(C)=CC=C5)C)=C1)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Qi J, et al. Effective Targeting of the Survivin Dimerization Interface with Small-Molecule Inhibitors. Cancer research. 2016 Jan 15;76(2):453-62.

[2]. Martínez-García D, et al. Therapeutic strategies involving survivin inhibition in cancer. Medicinal research reviews. 2019 May;39(3):887-909.

[3]. Li F, et al. Cancer therapeutics using survivin BIRC5 as a target: what can we do after over two decades of study?. Journal of experimental & clinical cancer research : CR. 2019 Aug 22;38(1):368.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References

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LQZ-7