LY-272015 hydrochloride
Based on 1 Customer Validation
LY-272015 hydrochloride is an orally active and selective 5-HT2B receptor antagonist. LY-272015 hydrochloride blocks 5-HT2 receptors and inhibits Fluoxetine (HY-B0102)-induced PDGFβ receptor transactivation. LY-272015 hydrochloride attenuates 5-HT-induced smooth muscle cell migration and proliferation, and inhibits downstream mTOR/p70S6K phosphorylation. LY-272015 hydrochloride reduces 5-HT-induced vasoconstriction. LY-272015 hydrochloride reverses the excitatory effect of BW-723C86 (HY-101369) on NTS neurons. LY-272015 hydrochloride lowers mean arterial blood pressure in severely hypertensive DOCA-salt rats. LY-272015 hydrochloride can be used in research related to diseases such as hypertension and cardiovascular calcification.
For research use only. We do not sell to patients.
- Purity : 99.89%
- CAS No.: 172895-15-7
- Formula: C21H25ClN2O2
- Molecular Weight:372.89
-
Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
-
Solvent & Solubility
- Protocols
- Purity & Documentation
- References
-
Help & FAQs
All 5-HT Receptor Isoforms
More
Biological Activity
Description
IC50 & Target
[1]|
5-HT2B Receptor |
PDGFRβ |
mTOR |
In Vitro
LY-272015 (100 nmol/L; 0-24 h) hydrochloride attenuates 5-HT-induced migration and proliferation of rat aortic SMCs[2].
LY-272015 (10 nmol/L; 2 h) hydrochloride antagonizes 5-HT-induced activation of the mTOR/p70S6K pathway in rat aortic SMCs[2].
LY 272015 (2.87 μg/mL; 5 min) hydrochloride had no significant effect on the amplitude or frequency of phrenic nerve discharge in isolated perfused brainstem preparations from Sprague-Dawley rats[3].
LY-272015 hydrochloride right-shifted the BW-723C86 (HY-101369)-induced contraction curve in endothelium-denuded mesenteric arteries of DOCA-salt rats, confirming the involvement of vascular 5-HT2B receptors in the increase[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
- Scratch/Wound-Healing Migration Assay
- Western Blot
- Cell migration
- Neural Crest/Neuronal Cell Migration Explant Assay
- Research Protocol for Cardiovascular Diseases
- Cell Viability Determination by MTT Colorimetric Assay
- Kinase activity and phosphorylation assays
- Zigmond Chamber Chemotaxis Assay
- Under-Agarose Cell Migration Assay
- Transwell/Boyden Chamber Migration Assay
- 3D Collagen/Hydrogel Matrix Migration Assay
- Protocol for Kinase activity and phosphorylation assays
- Cell-Exclusion Zone Migration Assay
- Dunn/Insall Chamber Chemotaxis Assay
Chemical Information
-
CAS No. 172895-15-7
-
Appearance Solid
-
Molecular Weight 372.89
-
Formula C21H25ClN2O2
-
Color Off-white to light yellow
-
SMILES
CC1=CC2=C(NC3=C2CCNC3CC4=CC=C(OC)C(OC)=C4)C=C1.[H]Cl
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
In Vitro:
DMSO : 5 mg/mL (13.41 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
-
Data Sheet (290 KB)
-
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
-
Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.6818 mL | 13.4088 mL | 26.8176 mL | 67.0439 mL |
| 5 mM | 0.5364 mL | 2.6818 mL | 5.3635 mL | 13.4088 mL | |
| 10 mM | 0.2682 mL | 1.3409 mL | 2.6818 mL | 6.7044 mL |
LY-272015 hydrochloride Related Classifications
HY-100851A Related Classifications
Powered by Bioz
Keywords