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Cat. No.: HY-184057

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M1 receptor modulator-1

M1 receptor modulator-1 is a low-efficacy positive allosteric modulator of the muscarinic M1 receptor (mAChR1), with an EC₅₀ of 71 nM for the human M1 receptor. M1 receptor modulator-1 enables use-dependent attenuation of neurotransmitter signals and exhibits excellent in vivo properties without pseudo-agonist activity. M1 receptor modulator-1 can be used in research related to Alzheimer's disease and schizophrenia.

For research use only. We do not sell to patients.

CAS No.: 34099-70-2
Formula: C₁₅H₁₁BrN₂S
Molecular Weight:331.23

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

M1 receptor modulator-1 Chemical Structure

CAS No.: 34099-70-2

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
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Biological Activity

Description

IC₅₀ & Target

^[1]

mAChR1

71 nM (EC₅₀)

All mAChR Isoforms :

In Vitro

M1 receptor modulator-1 (Compound 52)(up to 10,000 nM; up to 24 μM; 10 μM) is a potent, selective low-shift positive allosteric modulator of human and rat muscarinic M1 receptors, with an EC₅₀ of 71 nM at human M1 receptors, and exhibits favorable drug metabolism properties in human and mouse microsomes^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Alzheimer’s Disease Modeling

Chemical Information

CAS No. 34099-70-2
Molecular Weight 331.23
Formula C₁₅H₁₁BrN₂S
SMILES

S=C1NC2=C(C(C3=CC=CC=C3)=NC1)C=C(Br)C=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Flohr A, et al.. Discovery of the first low-shift positive allosteric modulators for the muscarinic M1 receptor. Bioorganic & medicinal chemistry letters. 2017 Dec 15;27(24):5415-5419. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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