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Cat. No.: HY-158485

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M5 glycan (Man5)

Name: M5 glycan (Man5)
Brand: MedChemExpress
SKU: HY-158485
Availability: PreOrder

(Synonyms: Mannose-5 N-linked oligosaccharide; Oligomannose 5 glycan)

M5 glycan (Man5) (Mannose-5 N-linked oligosaccharide; Oligomannose 5 glycan) is an N-linked glycan on glycoproteins on glycoproteins. M5 glycan (Man5) enhances antibody-dependent cell-mediated cytotoxicity and reduces complement-dependent cytotoxicity.

For research use only. We do not sell to patients.

CAS No.: 66091-47-2

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (257 KB)

M5 glycan (Man5) Chemical Structure

CAS No.: 66091-47-2

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
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Calculators
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Biological Activity

Description

In Vitro

Adaptive ImmunityAnti-cancer

Adaptive Immunity

Anti-cancer

When the proportion of M5 glycan (Man5) on mAb1 reaches 62%, 78% or 86%, it exhibits 5- to 7-fold higher ADCC activity against WIL2-S cells than complex fucosylated mAb1^[1].
When present on mAb1 at levels of 62%, 78%, or 86%, M5 glycan (Man5) reduces the CDC activity against WIL2-S cells by 50% compared to fucosylated complex-type mAb1^[1].

Adaptive Immunity

When the proportion of M5 glycan (Man5) on mAb1 reaches 62%, 78% or 86%, its binding affinity to FcγRIA is comparable to that of fucosylated complex-type mAb1, while its binding affinities to FcγRIIA and FcγRIIB are reduced, and its binding affinities to FcγRIIIA allotypes are increased by 4-8 folds^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Chemical Information

CAS No. 66091-47-2
Synonyms

Mannose-5 N-linked oligosaccharide; Oligomannose 5 glycan
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (257 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Yu M, et al. Production, characterization, and pharmacokinetic properties of antibodies with N-linked mannose-5 glycans. mAbs. 2012;4(4):475-87. [Content Brief]

[2]. Jiménez-Castells C, et al. Development of a multifunctional aminoxy-based fluorescent linker for glycan immobilization and analysis. Glycobiology. 2016 Dec;26(12):1297-1307. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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