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Cat. No.: HY-186242

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Magnolol-C4-TPP bromide

Magnolol-C4-TPP bromide is a mitochondria-targeted magnolol derivative with cytotoxic activity against cancer cells. Magnolol-C4-TPP bromide increases ROS levels and slightly reduces mitochondrial membrane potential in colon cancer cells. Magnolol-C4-TPP bromide can be used in the research of colorectal cancer, liver cancer, and breast cancer.

For research use only. We do not sell to patients.

CAS No.: 3123944-18-0
Formula: C₄₀H₄₀BrO₂P
Molecular Weight:663.62

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Magnolol-C4-TPP bromide Chemical Structure

CAS No.: 3123944-18-0

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
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Biological Activity

Description

In Vitro

Anti-cancerMitochondrial FunctionOxidative Stress

Anti-cancer

Magnolol-C4-TPP bromide (Compound MT1) (48 h) potently inhibits the proliferation of SW480, CT26, HCT116, HepG2 and MDA-MB-231 cancer cells, with IC₅₀ values of 8.23, 8.51, 3.28, 6.25 and 4.35 μM after 48 h of incubation^[1].

Mitochondrial Function

Magnolol-C4-TPP bromide (4 μM; 24 h) slightly reduces the mitochondrial membrane potential of SW480 cells after 24 h of incubation^[1].

Oxidative Stress

Magnolol-C4-TPP bromide (4 μM; 24 h) increases intracellular ROS levels in SW480 cells after 24 h of incubation^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Anti-cancerOxidative Stress

Anti-cancer

Oxidative Stress

Magnolol-C4-TPP bromide (Compound MT1) (4 mg/kg; i.v.; daily; 14 days) induces reactive oxygen species production in MC38 tumor-bearing C57BL/6 mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

C57BL/6 (female, 6-8 weeks old, subcutaneously injected with 1.0 × 10^6 MC38 colon carcinoma cells)^[1]
Dosage:

4 mg/kg
Administration:

i.v.; daily; 14 days
Result:

Increased red fluorescence in tumor tissue (indicating ROS production), though less intense than the MTP treatment group.

Related Protocols :

Chemical Information

CAS No. 3123944-18-0
Molecular Weight 663.62
Formula C₄₀H₄₀BrO₂P
SMILES

OC1=C(C2=CC(CC=C)=CC=C2OCCCC[P+](C3=CC=CC=C3)(C4=CC=CC=C4)C5=CC=CC=C5)C=C(CC=C)C=C1.[Br-]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Wang Y, et al. Mitochondrion-targeted magnolol derivatives exert synergistic anticancer activity by modulating energy metabolism and tumor microenvironment. European journal of medicinal chemistry. 2026 Jan 15;302(Pt 1):118265. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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