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Cat. No.: HY-187514

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MAHS-4

MAHS-4 is an inhibitor of thymidylate synthase (TS) and dihydrofolate reductase (DHFR), with IC₅₀ values of 1.918 μM and 83.53 μM, respectively. MAHS-4 inhibits thymidylate biosynthesis, reduces tetrahydrofolate pool maintenance, and interferes with extracellular matrix remodeling. MAHS-4 induces G2/M phase cell cycle arrest, activates endogenous caspase-dependent apoptosis, decreases MMP protein levels, inhibits cell migration, increases intracellular NO levels, and promotes autophagy activity. MAHS-4 is applicable for cancer-related research.

For research use only. We do not sell to patients.

Formula: C₂₂H₁₆ClFN₆O₃
Molecular Weight:466.85

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

MAHS-4 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

^[1]

Caspase-7

Caspase-9

MMP-7

MMP-9

PARP-1

Bcl-xL

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All Bcl-2 Family Isoforms :

All Caspase Isoforms :

All PARP Isoforms :

All MMP Isoforms :

In Vitro

Anti-cancerCell Cycle Regulation

Anti-cancer

Cell Cycle Regulation

MAHS-3 induces cell cycle arrest and upregulates the expression of p21 and p27; it activates endogenous caspase-dependent apoptosis and regulates the levels of Bax, Cas-7, Cas-9, Bcl-2 and PARP1^[1].

Anti-cancer

MAHS-4 exhibits dose-dependent antiproliferative activity in various cancer cell lines, shows cytostatic activity in some cancer cell lines, and has significantly higher cytotoxicity against breast cancer cells than normal cells and non-tumorigenic cells; moreover, it has better cancer cell selectivity than MAHS-3 (HY-187513)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Chemical Information

Molecular Weight 466.85
Formula C₂₂H₁₆ClFN₆O₃
SMILES

CC1=NN(C2=CC=C(F)C=C2)C(N=C(CCl)N3CC4=NO[N+]([O-])=C4C5=CC=CC=C5)=C1C3=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Alotaibi FS, et al. Synthesis of N5-furoxan-functionalized pyrazolo[3,4-d]pyrimidinones as novel nonclassical DHFR/TS inhibitors with potential apoptotic and anti-migratory activity. Bioorganic chemistry. 2026 Jul 20;181:110269.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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MAHS-4

All Bcl-2 Family Isoforms

All Caspase Isoforms

All PARP Isoforms

All MMP Isoforms