country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-184384

Copy Link Print Information

MetAP-2 modulator-1

MetAP-2 modulator-1 is a MetAP-2 modulator. MetAP-2 modulator-1 reduces the MetAP-2 enzyme level in cells. MetAP-2 modulator-1 exhibits anticancer effects against neuroblastoma. MetAP-2 modulator-1 can be used in studies related to neuroblastoma.

For research use only. We do not sell to patients.

Formula: C₂₀H₁₅FN₄O₂S
Molecular Weight:394.42

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

MetAP-2 modulator-1 Chemical Structure

Price

Stock

Quantity

Amount: USD 0.00

* Please select Quantity before adding items.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

In Vitro

MetAP-2 modulator-1 (Compound 4e) (2.5 μg/mL; 24 h) significantly reduces MetAP-2 enzyme levels in human neuroblastoma SH-SY5Y cells, resulting in a measured level of 8.8 ng/μg protein after 24 h exposure at 2.5 μg/mL^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

ELISA Assay^[1]

Cell Line:

human neuroblastoma SH-SY5Y cells
Concentration:

2.5 μg/mL
Incubation Time:

24 h
Result:

Reduced MetAP-2 level to 8.8 ng/μg protein, which was a significant decrease compared to unexposed control cells (56.4 ng/μg protein) and positive control fumagillin (85.9 ng/μg protein).

Chemical Information

Molecular Weight 394.42
Formula C₂₀H₁₅FN₄O₂S
SMILES

OC1=CC=C(C=C1)/C=N/NC(CC2=CSC3=NC(C4=CC=C(C=C4)F)=CN23)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Camci Eren M, et al. Discovery of novel imidazo[2,1-b]thiazole-hydrazone hybrids as multi-target anticancer agents: Dual PARP-1/COX-2 inhibition and MetAP-2 modulation. Bioorg Chem. 2026 Jun 1;180:110066. [Content Brief]

Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

Get Quote In-stock

Other size

Get Quote