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Cat. No.: HY-189014

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Methoxymethyl-MTEP

Methoxymethyl-MTEP is a selective, high-affinity mGluR5 antagonist. Methoxymethyl-MTEP can serve as a radiotracer ligand, readily entering the brain and providing mGluR5-specific signal in gray matter regions. Methoxymethyl-MTEP exhibits a K_d = 20 nM as measured by saturation binding assays in rat brain cell membranes, and an IC₅₀ = 30 nM in competitive binding assays. Methoxymethyl-MTEP can be used for research on diseases related to the glutamatergic nervous system, such as excitotoxicity and schizophrenia.

For research use only. We do not sell to patients.

CAS No.: 524924-75-2
Formula: C₁₃H₁₂N₂OS
Molecular Weight:244.31

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Methoxymethyl-MTEP Chemical Structure

CAS No.: 524924-75-2

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
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Biological Activity

Description

IC₅₀ & Target

^[1]

mGluR5

All mGluR Isoforms :

In Vitro

Methoxymethyl-MTEP (10 μM) shows negligible binding to a large number of neurotransmitter receptors^[1].
The radioactive form of Methoxymethyl-MTEP, [³H]-methoxymethyl-MTEP, can be used for mGlu5 receptor binding and characterization studies^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Methoxymethyl‑MTEP (radioligand; 50 μCi/kg; intravenous injection) achieves rapid brain penetration in wild‑type rats, with specific binding intensity in the hippocampus being 12 times that in the cerebellum^[1].
Methoxymethyl‑MTEP (radioligand; 50 μCi/kg; intravenous injection) exhibits only background levels of specific binding in the forebrain of mGlu₅ knockout mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 524924-75-2
Molecular Weight 244.31
Formula C₁₃H₁₂N₂OS
SMILES

COCC1=CC(C#CC2=CSC(C)=N2)=CN=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Anderson JJ, et al. [3H]Methoxymethyl-3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine binding to metabotropic glutamate receptor subtype 5 in rodent brain: in vitro and in vivo characterization. The Journal of pharmacology and experimental therapeutics. 2002 Dec;303(3):1044-51.

[2]. Williams T, et al. Activation of the mGlu₅ Receptor for the Treatment of Schizophrenia and Cognitive-Deficit-Associated Disorders. In: Celanire S, Poli S (eds). Small Molecule Therapeutics for Schizophrenia. Topics in Medicinal Chemistry, vol 13. Springer, Cham; 2014.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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