Methyl-2-bromo-LSD
Based on 1 Customer Validation
Methyl-2-bromo-LSD is a blood-brain barrier-penetrant serotonin 5-HT2 receptor ligand and PET imaging agent that binds 5-HT2 receptors with high affinity and achieves selective labeling of cortical regions. Methyl-2-bromo-LSD is useful for research on Alzheimer's disease, depression, schizophrenia, and anxiety disorders.
For research use only. We do not sell to patients.
- Purity : 98.39%
- CAS No.: 50484-98-5
- Formula: C21H26BrN3O
- Molecular Weight:416.35
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Protocols
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Description
IC50 & Target
[1]|
5-HT2 Receptor |
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Papio anubis (adult male, 55 kg, anesthetized with Ketaset, 2% suritol, atropine)[1]
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Dosage:0.1 μg/kg
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Administration:i.v.; single dose
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Result:Led to selective labeling of cortical brain regions, with highest activity in cortical areas and low activity in the cerebellum.
Showed significantly reduced cortical activity following ketanserin blockade.
Chemical Information
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CAS No. 50484-98-5
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Appearance Solid
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Molecular Weight 416.35
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Formula C21H26BrN3O
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Color White to light yellow
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SMILES
BrC1=C2C3=C(C=CC=C3C4=C[C@H](CN([C@@]4(C2)[H])C)C(N(CC)CC)=O)N1C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
In Vitro:
DMSO : 100 mg/mL (240.18 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (6.00 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (6.00 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (281 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.4018 mL | 12.0091 mL | 24.0183 mL | 60.0456 mL |
| 5 mM | 0.4804 mL | 2.4018 mL | 4.8037 mL | 12.0091 mL | |
| 10 mM | 0.2402 mL | 1.2009 mL | 2.4018 mL | 6.0046 mL | |
| 15 mM | 0.1601 mL | 0.8006 mL | 1.6012 mL | 4.0030 mL | |
| 20 mM | 0.1201 mL | 0.6005 mL | 1.2009 mL | 3.0023 mL | |
| 25 mM | 0.0961 mL | 0.4804 mL | 0.9607 mL | 2.4018 mL | |
| 30 mM | 0.0801 mL | 0.4003 mL | 0.8006 mL | 2.0015 mL | |
| 40 mM | 0.0600 mL | 0.3002 mL | 0.6005 mL | 1.5011 mL | |
| 50 mM | 0.0480 mL | 0.2402 mL | 0.4804 mL | 1.2009 mL | |
| 60 mM | 0.0400 mL | 0.2002 mL | 0.4003 mL | 1.0008 mL | |
| 80 mM | 0.0300 mL | 0.1501 mL | 0.3002 mL | 0.7506 mL | |
| 100 mM | 0.0240 mL | 0.1201 mL | 0.2402 mL | 0.6005 mL |
Methyl-2-bromo-LSD Related Classifications
HY-186244 Related Classifications
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