(-)-Maritoclax
(-)-Maritoclax ((-)-Marinopyrrole A) is an actin-targeting cytotoxic and antibacterial agent. (-)-Maritoclax exhibits cytotoxicity against cancer cells. (-)-Maritoclax can be used in the research of methicillin-resistant Staphylococcus aureus infections and colon cancer.
For research use only. We do not sell to patients.
- CAS No.: 1010732-14-5
- Formula: C22H12Cl4N2O4
- Molecular Weight:510.15
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HCT-116 | IC50 |
8.8 μM
Compound: 40
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Anticancer activity against human HCT-116 cells assessed as cell growth inhibition
Anticancer activity against human HCT-116 cells assessed as cell growth inhibition
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[PMID: 36058089] |
| HCT-116 | IC50 |
4.5 μg/mL
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Cytotoxicity against human HCT-116 colon cancer cells, quantified as inhibition of cell viability.
Cytotoxicity against human HCT-116 colon cancer cells, quantified as inhibition of cell viability.
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20405892 |
| HeLa | IC50 |
20 μM
Compound: Marinopyrrole A
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Cytotoxicity against human HeLa cells assessed as reduction in cell viability after 72 hrs
Cytotoxicity against human HeLa cells assessed as reduction in cell viability after 72 hrs
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[PMID: 29407973] |
| RS4-11 | IC50 |
2 μM
Compound: Marinopyrrole A
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Cytotoxicity against human RS4:11 cells assessed as reduction in cell viability after 72 hrs
Cytotoxicity against human RS4:11 cells assessed as reduction in cell viability after 72 hrs
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[PMID: 29407973] |
In Vitro
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1010732-14-5
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Molecular Weight 510.15
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Formula C22H12Cl4N2O4
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SMILES
O=C(C=1C=CC=CC1O)C2=CC(Cl)=C(Cl)N2C=3C(Cl)=C(Cl)NC3C(=O)C=4C=CC=CC4O
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Synonyms
(-)-Marinopyrrole A
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Structure Classification
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Initial Source
Streptomyces sp. CNQ-418
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
(-)-Maritoclax Related Classifications
HY-15613A Related Classifications
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