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Cat. No.: HY-189882

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MKT-077-NH2 TFA

MKT-077-NH2 TFA is a MKT-077 (HY-15096) derivative bearing an aminoethylpyridinium substituent. MKT-077-NH2 TFA serves as an intermediate for organic synthesis-related research, such as acting as the Hsc70 ligand of Hsc70TAC BRD4 degrader-1 (HY-189881).

For research use only. We do not sell to patients.

Formula: C₂₃H₂₄F₃N₄O₃S₂⁺
Molecular Weight:525.59

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

MKT-077-NH2 TFA Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
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Biological Activity

Description

All HSP Isoforms :

In Vitro

MKT-077-NH2 (compound 10) TFA can serve as the Hsc70 ligand for Hsc70TAC BRD4 degrader-1 (HY-189881)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Molecular Weight 525.59
Formula C₂₃H₂₄F₃N₄O₃S₂⁺
SMILES

FC(F)(F)C(O)=O.O=C1N(CC)/C(S/C1=C2SC3=CC=CC=C3N/2C)=C/C4=CC=CC=[N+]4CCN
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Chen C, et al. Hsc70‑Mediated Targeting Chimeras for Targeted Protein Degradation via Chaperone‑Mediated Autophagy. Journal of Medicinal Chemistry. 2026.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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