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Cat. No.: HY-174955B

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mPEG5000-Silane

Name: mPEG5000-Silane
Brand: MedChemExpress
SKU: HY-174955B
Price: 25.00 USD
Availability: InStock
Rating: 5 (1 reviews)

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mPEG5000-Silane is a PEG derivative containing silane that can be used to modify glass, silicon or other surfaces by reacting the hydroxyl groups with ethoxy (methoxy) silane.

For research use only. We do not sell to patients.

Purity : 99.89%
Molecular Weight:5000 (Average)

Storage:

Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month

mPEG5000-Silane Chemical Structure

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Solvent & Solubility
- In Vitro
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

mPEG5000-Silane is a PEG derivative containing silane that can be used to modify glass, silicon or other surfaces by reacting the hydroxyl groups with ethoxy (methoxy) silane^[1].

In Vitro

OthersInnate Immunity

Others

mPEG5000-Silane (25-800 mg; 24 h) successfully grafts to 40-nm silica nanoparticles, with higher grafting efficiency at lower mPEG5000-Silane concentrations, as confirmed by infrared spectroscopy and thermogravimetry^[1].
mPEG5000-Silane (25-800 mg; 1 h) coating on silica nanoparticles reduces BSA adsorption, with the most heavily pegylated sample (S800a) showing the lowest protein adsorption^[1].

Innate Immunity

mPEG5000-Silane (0.065 mg/mL; 24-48 h) coating reduces silica nanoparticle cytotoxicity to RAW 264.7 macrophages and primary human fibroblasts, with high pegylation (sample S800a) providing the greatest biocompatibility; BSA pre-coating (50 mg/mL; 1 h) enhances macrophage uptake and reduces viability but preserves fibroblast viability^[1].
mPEG5000-Silane (1.5 mg/mL; 3-24 h) coating on fluorescent silica nanoparticles dramatically reduces uptake by RAW 264.7 macrophages, with mean fluorescence intensity values 40-50 times lower than bare nanoparticles across 3 h, 5 h, and 24 h incubation times^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Appearance Solid
Molecular Weight 5000 (Average)
Color White to off-white
SMILES

CCO[Si](CCCNC(OCCOC)=O)(OCC)OCC.[n]
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (265 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Malgorzata Sikorska, et al. Lack of cytotoxic and genotoxic effects of mPEG-silane coated iron(III) oxide nanoparticles doped with magnesium despite cellular uptake in cancerous and noncancerous lung cells. Toxicol In Vitro. 2024 Aug:99:105850. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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Minimum order quantity

100 mg

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