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Cat. No.: HY-P4130

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MPS-Gαi2

MPS-Gαi2 is a membrane-permeable inhibitory peptide corresponding to the C-terminal sequence of Gαi2 involved in receptor interaction. MPS-Gαi2 blocks Hep I-induced binding of Gαi2 to LRP, thereby inhibiting pertussis toxin-sensitive Gαi2 signaling and focal adhesion disassembly mediated by thrombospondin/Hep I-calreticulin-LRP. MPS-Gαi2 can be used in studies on G protein signaling and cell adhesion regulation.

For research use only. We do not sell to patients.

CAS No.: 1180485-56-6
Formula: C₁₁₉H₂₀₃N₂₉O₃₀S
Molecular Weight:2552.13

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

MPS-Gαi2 Chemical Structure

CAS No.: 1180485-56-6

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

In Vitro

MPS-Gαi2 (1 μM; 1 h incubation) specifically inhibits the binding of Gαi2 to LRP in bovine aortic endothelial cells stimulated by hep I, and abolishes the approximately 2.8-fold increase in binding levels induced by hep I treatment^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1180485-56-6
Molecular Weight 2552.13
Formula C₁₁₉H₂₀₃N₂₉O₃₀S
Sequence

Ala-Ala-Val-Ala-Leu-Leu-Pro-Ala-Val-Leu-Leu-Ala-Leu-Leu-Ala-Lys-Asn-Asn-Leu-Lys-Asp-Cys-Gly-Leu-Phe
Sequence Shortening

AAVALLPAVLLALLAKNNLKDCGLF
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (258 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Orr AW, et al. Low density lipoprotein receptor-related protein is a calreticulin coreceptor that signals focal adhesion disassembly. The Journal of cell biology. 2003 Jun 23;161(6):1179-89. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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