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Cat. No.: HY-189488

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Multi-target kinase-IN-11

Multi-target kinase-IN-11 (compound 2a) is a potent multi-target inhibitor of Cholinesterase and Carbonic Anhydrase. Multi-target kinase-IN-11 inhibits AChE, BChE, hCA I, and hCA II with IC₅₀ values of 2.78, 4.88, 0.94, and 4.15 μM, respectively. Multi-target kinase-IN-11 inhibits these enzymes through hydrogen bonding and electrostatic interactions with active site residues. Multi-target kinase-IN-11 can be used for research on Alzheimer's disease.

For research use only. We do not sell to patients.

Formula: C₅₀H₂₈N₁₀O₆Si
Molecular Weight:892.91

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Multi-target kinase-IN-11 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

IC₅₀ & Target

^[1]

hCA I

0.94 μM (IC₅₀)

hCA II

4.15 μM (IC₅₀)

AChE

2.78 μM (IC₅₀)

BChE

4.88 μM (IC₅₀)

All Cholinesterase (ChE) Isoforms :

AChE
BChE

All Carbonic Anhydrase Isoforms :

In Vitro

Multi-target kinase-IN-11 (compound 2a) (3-10 min) effectively inhibits hCA I (IC₅₀ = 0.94 μM), hCA II (IC₅₀ = 4.15 μM), AChE (IC₅₀ = 2.78 μM), and BChE (IC₅₀ = 4.88 μM) in vitro^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Alzheimer’s Disease Modeling

Chemical Information

Molecular Weight 892.91
Formula C₅₀H₂₈N₁₀O₆Si
SMILES

O=C(N1CO[Si]234(OCN5C(C6=CC=CC=C6C5=O)=O)[N]7=C8N=C9N2C(C%10=C9C=CC=C%10)=NC%11=[N]3C(C%12=C%11C=CC=C%12)=NC%13=C%14C=CC=CC%14=C(N=C7C%15=C8C=CC=C%15)N%134)C%16=CC=CC=C%16C1=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Ünlü S, et al. Quinoline and Phthalimide Substituted Silicon Phthalocyanines as Multi-Target Inhibitors of Cholinesterases and Carbonic Anhydrases. Journal of biochemical and molecular toxicology. 2026 Sep;40(9):e71090.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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