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Cat. No.: HY-N21881

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Muraminomicin F

Muraminomicin F is a lipopeptide nucleoside antibiotic and MraY inhibitor (IC₅₀ = 8.9 ng/mL). Muraminomicin F exerts antibacterial effects by inhibiting MraY, an essential key enzyme in bacterial cell wall peptidoglycan biosynthesis. Muraminomicin F can be used in research on bacterial infections.

For research use only. We do not sell to patients.

CAS No.: 695226-94-9
Formula: C₅₅H₈₇N₅O₂₃
Molecular Weight:1186.30

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Muraminomicin F Chemical Structure

CAS No.: 695226-94-9

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

IC₅₀ & Target

^[1]

Lipopeptide

All Antibiotic Isoforms :

In Vitro

Bacterial InfectionOthers

Bacterial Infection

Muraminomicin F (18 h) exhibits excellent antibacterial activity against various Gram-positive bacteria, including MRSA and PRSP, and its antibacterial activity decreases with the addition of serum^[1].

Others

Muraminomicin F strongly inhibits the MraY enzymatic reaction in a cell-free enzyme assay system, with IC₅₀ = 8.9 ng/mL^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Bacterial Infection

Muraminomicin F shows no therapeutic effect in the mouse systemic infection model, possibly due to the influence of serum^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Research Protocol for Infectious Diseases

Chemical Information

CAS No. 695226-94-9
Molecular Weight 1186.30
Formula C₅₅H₈₇N₅O₂₃
SMILES

NC[C@H]([C@H](C1)O)O[C@H]1OC([C@@H]2N(C[C@@H]([C@H](N(C2=O)C)C(O)=O)OC(CC(CCCCCCCCCCC)OC(CC(C)CC(O[C@H]3[C@@H]([C@@H]([C@H]([C@@H](O3)CC)OC)OC(CCC(O)=O)=O)OC)=O)=O)=O)C)[C@H]4O[C@@H](N5C(NC(C=C5)=O)=O)C[C@@H]4O
Structure Classification
- Ketones, Aldehydes, Acids
Initial Source
- Microorganism
Streptosporangium sp.
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Fujita Y, et al. Muraminomicins, new lipo-nucleoside antibiotics from Streptosporangium sp. SANK 60501-structure elucidations of muraminomicins and supply of the core component for derivatization. J Antibiot (Tokyo). 2019 Dec;72(12):943-955.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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