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Cat. No.: HY-189098

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N-0159

N-0159 is a type II transmembrane serine protease (TTSP) inhibitor with anti-influenza virus activity. N-0159 exhibits a K_i of 0.06 nM against matriptase and acts through competitive and reversible inhibition of matriptase catalytic activity. N-0159 inhibits H1N1 influenza virus replication in human bronchial epithelial cells (IC₅₀ = 292 nM). N-0159 can be used for research related to influenza virus infection.

For research use only. We do not sell to patients.

CAS No.: 3068741-64-7
Formula: C₃₄H₄₈N₁₂O₅S
Molecular Weight:736.89

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Please store the product under the recommended conditions in the Certificate of Analysis.

N-0159 Chemical Structure

CAS No.: 3068741-64-7

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
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Biological Activity

Description

Cellular Effect

Cell Line	Type	Value	Description	References
Calu-3	IC50	292 nM	Inhibition of H1N1 virus replication in human bronchial epithelial Calu-3 cells infected with A/Puerto Rico/8/34 (PR8) at an MOI of 0.003, with viral titers evaluated 48 hrs post-infection. Inhibition of H1N1 virus replication in human bronchial epithelial Calu-3 cells infected with A/Puerto Rico/8/34 (PR8) at an MOI of 0.003, with viral titers evaluated 48 hrs post-infection.	37864572

In Vitro

OthersViral Infection

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N-0159 (compound 15d) effectively inhibits recombinant human matriptase with a K_i value of 0.06 nM.
N‑0159 features homophenylalanine at the P2 position, which increases side‑chain flexibility and promotes additional π‑aromatic interactions within the matriptase active site, accounting for its higher affinity relative to IN‑2^[1].

Viral Infection

N-0159 inhibits H1N1 virus replication in Calu-3 cells with an IC₅₀ of 292 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Research Protocol for Infectious Diseases

Chemical Information

CAS No. 3068741-64-7
Molecular Weight 736.89
Formula C₃₄H₄₈N₁₂O₅S
SMILES

N=C(N)NCCC[C@H](N)C(N[C@@H](CCC(N)=O)C(N[C@@H](CCC1=CC=CC=C1)C(N[C@@H](CCCNC(N)=N)C(C2=NC3=CC=CC=C3S2)=O)=O)=O)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Colombo É, et al. Optimization of Ketobenzothiazole-Based Type II Transmembrane Serine Protease Inhibitors to Block H1N1 Influenza Virus Replication. ChemMedChem. 2024 Jan 15;19(2):e202300458.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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