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Cat. No.: HY-402216

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N-b-Hydroxyethyl oleyl imidazoline

N-b-Hydroxyethyl oleyl imidazoline is a selective enzyme inhibitor targeting DIO, with an IC₅₀ of 3.9 μM against human DIO3. N-b-Hydroxyethyl oleyl imidazoline binds to the catalytic domain of deiodinase and blocks the deiodination catalytic reaction of thyroid hormone molecules. N-b-Hydroxyethyl oleyl imidazoline can be used in studies related to the functional regulation of thyroid deiodinases.

For research use only. We do not sell to patients.

CAS No.: 95-38-5
Formula: C₂₂H₄₂N₂O
Molecular Weight:350.59

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

N-b-Hydroxyethyl oleyl imidazoline Chemical Structure

CAS No.: 95-38-5

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
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Biological Activity

Description

In Vitro

N-b-Hydroxyethyl oleyl imidazoline (95-38-5) (0.032-200 μM; 3 h) inhibits the activity of human DIO3 in HEK293 cell lysates, with an IC₅₀ of 3.9 μM and an inhibition rate of 101% at the concentration of 200 μM; moreover, it achieves 50% or higher enzyme activity inhibition against all three types of deiodinases in single-point screening assays^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Research Protocol for Endocrine Diseases

Chemical Information

CAS No. 95-38-5
Molecular Weight 350.59
Formula C₂₂H₄₂N₂O
SMILES

OCCN1C(=NCC1)CCCCCCCC=CCCCCCCCC
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Olker JH, et al. Screening the ToxCast Phase 1, Phase 2, and e1k Chemical Libraries for Inhibitors of Iodothyronine Deiodinases. Toxicological sciences : an official journal of the Society of Toxicology. 2019 Apr 01;168(2):430-442. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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