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Cat. No.: HY-186247

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N-Myc-IN-1

N-Myc-IN-1 is a selective N-Myc inhibitor/degrader with a K_d value of 1.47 μM. N-Myc-IN-1 promotes phosphorylation of N-Myc at threonine-58, triggers N-Myc degradation via the ubiquitin-proteasome pathway, and suppresses the expression of N-Myc target genes. N-Myc-IN-1 reduces the viability of MYCN-dependent tumor cells and induces apoptosis. N-Myc-IN-1 can be used in the research of neuroblastoma.

For research use only. We do not sell to patients.

CAS No.: 885986-52-7
Formula: C₁₅H₁₃BrN₄O₂
Molecular Weight:361.19

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

N-Myc-IN-1 Chemical Structure

CAS No.: 885986-52-7

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
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Biological Activity

Description

In Vitro

Anti-cancerApoptosisOthers

Anti-cancer

N-Myc-IN-1 (Compound N78) (72 h) significantly inhibits the viability of N-Myc high-expressing cells such as SK-N-BE (2) and IMR-32^[1].

Apoptosis

N-Myc-IN-1 (1-8 μM; 8-48 h) induces apoptosis in SK-N-BE (2), IMR-32 and NB1 cells via degradation of N-Myc^[1].

Others

N-Myc-IN-1 (0-8 μM) promotes GSK3β-mediated phosphorylation of T58 to target N-Myc for ubiquitin-proteasomal degradation, rather than through the lysosomal pathway^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Apoptosis Analysis^[1]

Cell Line:

SK-N-BE(2), IMR-32, NB1 cells
Concentration:

2, 4 and 8 μM
Incubation Time:

48 h
Result:

Induced cell apoptosis.

Western Blot Analysis^[1]

Cell Line:

SK-N-BE(2), IMR-32, NB1 cells
Concentration:

1, 2, 4 and 8 μM
Incubation Time:

12 h
Result:

Increased cleaved-PARP and decreased BCL-XL.

In Vivo

Anti-cancerCell Cycle Regulation

Anti-cancer

Cell Cycle Regulation

N-Myc-IN-1 (Compound N78) (10-20 mg/kg; i.p.; i.p.; once daily for 18 days) is well-tolerated in mice and suppresses neuroblastoma tumor growth^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

BALB/c-nude (male, 6-8-week-old, subcutaneous xenograft model)^[1]
Dosage:

10 mg/kg; 20 mg/kg
Administration:

i.p.; once daily for 18 days
Result:

Achieved a tumor growth inhibition (TGI) value of 79.4%.
Achieved a tumor growth inhibition (TGI) value of 61.4%.
Significantly reduced tumor weights compared to controls.
Decreased Ki67 and N-Myc levels in tumor tissues.
Increased phosphorylation of N-Myc at threonine 58 in tumor tissues.
Was well-tolerated, with no significant mouse body weight loss or apparent toxicity in major organs.

Related Protocols :

Chemical Information

CAS No. 885986-52-7
Molecular Weight 361.19
Formula C₁₅H₁₃BrN₄O₂
SMILES

O=C(CBr)NC1=CC2=NN(C3=CC=C(C=C3)OC)N=C2C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Miao Y, et al. A Small Molecule Selectively Targets N-Myc to Suppress Neuroblastoma Cancer Progression. International journal of biological sciences. 2025;21(11):4895-4907. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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