N,N-Dimethyldoxorubicin
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Based on 1 Customer Validation
N,N-Dimethyldoxorubicin is an analog of Doxorubicin (HY-15142A). N,N-Dimethyldoxorubicin induces chromatin damage via histone eviction, while barely inducing DNA double-strand breaks. N,N-Dimethyldoxorubicin exhibits cytotoxicity against a variety of tumor cells. N,N-Dimethyldoxorubicin can be used in research related to multiple types of cancer.
For research use only. We do not sell to patients.
- Purity : 92.33%
- CAS No.: 70222-95-6
- Formula: C29H33NO11
- Molecular Weight:571.57
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Biological Activity
Description
N,N-Dimethyldoxorubicin is an analog of Doxorubicin (HY-15142A). N,N-Dimethyldoxorubicin induces chromatin damage via histone eviction, while barely inducing DNA double-strand breaks. N,N-Dimethyldoxorubicin exhibits cytotoxicity against a variety of tumor cells. N,N-Dimethyldoxorubicin can be used in research related to multiple types of cancer[1].
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
0.006 μM
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Cytotoxicity against human A549 cells assessed as reduction in cell viability after 2 h compound incubation followed by 72 h culture without compound, measured by CellTiter Blue viability assay.
Cytotoxicity against human A549 cells assessed as reduction in cell viability after 2 h compound incubation followed by 72 h culture without compound, measured by CellTiter Blue viability assay.
|
33783212 |
| BT-474 | IC50 |
0.355 μM
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Cytotoxicity against human BT474 cells assessed as reduction in cell viability after 2 h compound incubation followed by 72 h culture without compound, measured by CellTiter Blue viability assay.
Cytotoxicity against human BT474 cells assessed as reduction in cell viability after 2 h compound incubation followed by 72 h culture without compound, measured by CellTiter Blue viability assay.
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33783212 |
| BXPC-3 | IC50 |
0.135 μM
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Cytotoxicity against human BXPC3 cells assessed as reduction in cell viability after 2 h compound incubation followed by 72 h culture without compound, measured by CellTiter Blue viability assay.
Cytotoxicity against human BXPC3 cells assessed as reduction in cell viability after 2 h compound incubation followed by 72 h culture without compound, measured by CellTiter Blue viability assay.
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33783212 |
| DU-145 | IC50 |
0.190 μM
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Cytotoxicity against human DU145 cells assessed as reduction in cell viability after 2 h compound incubation followed by 72 h culture without compound, measured by CellTiter Blue viability assay.
Cytotoxicity against human DU145 cells assessed as reduction in cell viability after 2 h compound incubation followed by 72 h culture without compound, measured by CellTiter Blue viability assay.
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33783212 |
| FM3A | IC50 |
0.039 μM
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Cytotoxicity against human FM3 cells assessed as reduction in cell viability after 2 h compound incubation followed by 72 h culture without compound, measured by CellTiter Blue viability assay.
Cytotoxicity against human FM3 cells assessed as reduction in cell viability after 2 h compound incubation followed by 72 h culture without compound, measured by CellTiter Blue viability assay.
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33783212 |
| HCT-116 | IC50 |
0.042 μM
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Cytotoxicity against human HCT116 cells assessed as reduction in cell viability after 2 h compound incubation followed by 72 h culture without compound, measured by CellTiter Blue viability assay.
Cytotoxicity against human HCT116 cells assessed as reduction in cell viability after 2 h compound incubation followed by 72 h culture without compound, measured by CellTiter Blue viability assay.
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33783212 |
| HeLa | IC50 |
0.016 μM
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Cytotoxicity against human HeLa cells assessed as reduction in cell viability after 2 h compound incubation followed by 72 h culture without compound, measured by CellTiter Blue viability assay.
Cytotoxicity against human HeLa cells assessed as reduction in cell viability after 2 h compound incubation followed by 72 h culture without compound, measured by CellTiter Blue viability assay.
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33783212 |
| K562 | IC50 |
0.122 μM
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Cytotoxicity against human K562 cells assessed as reduction in cell viability after 2 h compound incubation followed by 72 h culture without compound, measured by CellTiter Blue viability assay.
Cytotoxicity against human K562 cells assessed as reduction in cell viability after 2 h compound incubation followed by 72 h culture without compound, measured by CellTiter Blue viability assay.
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33783212 |
| MEL-JUSO | IC50 |
0.046 μM
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Cytotoxicity against human MelJuSo cells assessed as reduction in cell viability after 2 h compound incubation followed by 72 h culture without compound, measured by CellTiter Blue viability assay.
Cytotoxicity against human MelJuSo cells assessed as reduction in cell viability after 2 h compound incubation followed by 72 h culture without compound, measured by CellTiter Blue viability assay.
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33783212 |
| PC-3 | IC50 |
0.122 μM
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Cytotoxicity against human PC3 cells assessed as reduction in cell viability after 2 h compound incubation followed by 72 h culture without compound, measured by CellTiter Blue viability assay.
Cytotoxicity against human PC3 cells assessed as reduction in cell viability after 2 h compound incubation followed by 72 h culture without compound, measured by CellTiter Blue viability assay.
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33783212 |
| SK-BR-3 | IC50 |
0.248 μM
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Cytotoxicity against human SKBR3 cells assessed as reduction in cell viability after 2 h compound incubation followed by 72 h culture without compound, measured by CellTiter Blue viability assay.
Cytotoxicity against human SKBR3 cells assessed as reduction in cell viability after 2 h compound incubation followed by 72 h culture without compound, measured by CellTiter Blue viability assay.
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33783212 |
| U2OS | IC50 |
0.028 μM
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Cytotoxicity against human U2Os cells assessed as reduction in cell viability after 2 h compound incubation followed by 72 h culture without compound, measured by CellTiter Blue viability assay.
Cytotoxicity against human U2Os cells assessed as reduction in cell viability after 2 h compound incubation followed by 72 h culture without compound, measured by CellTiter Blue viability assay.
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33783212 |
| U-87MG ATCC | IC50 |
0.006 μM
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Cytotoxicity against human U87 cells assessed as reduction in cell viability after 2 h compound incubation followed by 72 h culture without compound, measured by CellTiter Blue viability assay.
Cytotoxicity against human U87 cells assessed as reduction in cell viability after 2 h compound incubation followed by 72 h culture without compound, measured by CellTiter Blue viability assay.
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33783212 |
| U-118-MG | IC50 |
0.074 μM
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Cytotoxicity against human U118 cells assessed as reduction in cell viability after 2 h compound incubation followed by 72 h culture without compound, measured by CellTiter Blue viability assay.
Cytotoxicity against human U118 cells assessed as reduction in cell viability after 2 h compound incubation followed by 72 h culture without compound, measured by CellTiter Blue viability assay.
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33783212 |
In Vitro
Anti-cancerOthers
Anti-cancer
N,N-Dimethyldoxorubicin (10 μM; 2 h) barely induces DNA double-strand breaks in K562 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Western Blot Analysis[1]
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Cell Line:K562 cells
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Concentration:10 μM
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Incubation Time:2 h
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Result:Induced almost no DNA double-strand breaks, with minimal γH2AX signal normalized to actin and relative to etoposide.
Showed negligible broken DNA fraction in constant-field gel electrophoresis analysis.
Chemical Information
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CAS No. 70222-95-6
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Appearance Solid
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Molecular Weight 571.57
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Formula C29H33NO11
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SMILES
OC1=C2C(C(C3=C(OC)C=CC=C3C2=O)=O)=C(O)C([C@H]4O[C@H]5C[C@@H]([C@@H]([C@@H](O5)C)O)N(C)C)=C1C[C@](O)(C4)C(CO)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Purity & Documentation
Select Batch:
Purity:
99.98%
Assay:
99.98%
ee.:
99.98%
References
Calculators
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N,N-Dimethyldoxorubicin Related Classifications
HY-154797 Related Classifications
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