Nepetalactone

Nepetalactone (10 μM-10 mM; 15 min) induces a concentration-dependent repellent response in C. chinensis, D. citri, and M. usitatus^[1].
Nepetalactone (10 μM-1 mM; 10 min) elicits a sustained avoidance response in C. chinensis, D. citri, and M. usitatus in Y-tube olfactometer assays^[1].
Nepetalactone activates the TRPA1 orthologs CcTRPA1, DcTRPA1, and MuTRPA1 in HEK293T cells, with EC₅₀ values of 283.0 μM, 698.4 μM, and 172.5 μM, respectively^[1].
Nepetalactone (100 μM; 48 h) induces synergistic Ca²⁺ influx in HEK293T cells co-transfected with CcTRPA1 + CcPKCα or HaTRPA1 + HaCaMKII^[1].
Nepetalactone (100 μM; 10 min) induces a physical interaction between CcTRPA1 and CcPKCα and triggers calcium-dependent CcPKCα phosphorylation in HEK293T cells^[1].
Nepetalactone (100 μM; 10 min) induces a physical interaction between HaTRPA1 and HaCaMKII in HEK293T cells and triggers calcium-dependent HaCaMKII phosphorylation^[1].
Nepetalactone (100 μM; 300 ms pulse) activates TRPA1-expressing trichoid sensilla in C. chinensis, D. citri, and M. usitatus, and this response is eliminated by TRPA1 knockdown and attenuated by CcPKCα silencing^[1].
Nepetalactone (100 μM-10 mM) exhibits concentration-dependent attraction to H. axyridis and P. japonica, and this attraction is mediated by TRPA1^[1].
Nepetalactone induces calcium influx in HEK293T cells expressing HaTRPA1 or PjTRPA1^[1].
Nepetalactones are present in the essential oil of Nepeta crispa Willd., with a total content of 5.29% as determined by GC/MS analysis^[3].