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Cat. No.: HY-184695

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NH2-C16-azide

NH2-C16-azide is a 16-azidohexadecylamine derivative and synthetic intermediate, which can serve as a PROTAC Linker. NH2-C16-azide is applicable to research related to PROTAC synthesis, such as acting as the linker for PROTAC CDK9 degrader-13 (HY-184693).

For research use only. We do not sell to patients.

CAS No.: 2755836-98-5
Formula: C₁₆H₃₄N₄
Molecular Weight:282.47

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

NH2-C16-azide Chemical Structure

CAS No.: 2755836-98-5

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
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Biological Activity

Description

In Vitro

NH₂-C16-azide (compound 8f) serves as a linker for PROTAC CDK9 degrader-13 (HY-184693). PROTAC CDK9 degrader-13 is a selective CDK9 PROTAC degrader. It downregulates the anti-apoptotic protein Mcl-1 and activates the Caspase-3 pathway to induce apoptosis in acute myeloid leukemia cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2755836-98-5
Molecular Weight 282.47
Formula C₁₆H₃₄N₄
SMILES

NCCCCCCCCCCCCCCCCN=[N+]=[N-]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Li Q, et al. Discovery of selective CDK9 degraders with anti-AML activity using PROTAC technology. Bioorganic chemistry. 2026 Jun 12;180:110091. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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