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Cat. No.: HY-P11662A

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NLS peptide acetate

Name: NLS peptide acetate
Brand: MedChemExpress
SKU: HY-P11662A
Price: 100.00 USD
Availability: InStock
Rating: 5 (1 reviews)

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NLS peptide acetate is a nuclear localization signal peptide, a short amino acid sequence that can be recognized by nuclear transport machinery (such as the Importin protein complex). NLS peptide acetate can directionally transport the molecules or nanoparticles linked to it into the nucleus, and the N-terminal Cys terminus can be used for subsequent coupling. NLS peptide acetate can be used to construct nucleus-specific imaging probes and nucleus-targeted nanoparticles

For research use only. We do not sell to patients.

Formula: C₅₃H₉₈N₂₀O₁₄S·xC₂H₄O₂
Molecular Weight:1271.54 (free base)

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

NLS peptide acetate Chemical Structure

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

Chemical Information

Molecular Weight 1271.54 (free base)
Formula C₅₃H₉₈N₂₀O₁₄S·xC₂H₄O₂
SMILES

CC(O)=O.O=C(NCC(NCC(NCC(N1[C@@H](CCC1)C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCCN)C(N[C@@H](C(C)C)C(NCC(NCC(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CS)N.[x]
Sequence

Cys-Gly-Gly-Gly-Pro-Lys-Lys-Lys-Arg-Lys-Val-Gly-Gly
Sequence Shortening

CGGGPKKKRKVGG
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Ali MRK, et al. Nuclear Membrane-Targeted Gold Nanoparticles Inhibit Cancer Cell Migration and Invasion. ACS Nano. 2017;11(4):3716-3726. [Content Brief]

[2]. Nitin N, et al. NLS peptide conjugated molecular beacons for visualizing nuclear RNA in living cells. Bioconjug Chem. 2008;19(11):2205-2211. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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