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Cat. No.: HY-189119

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NMI-1182

NMI-1182 is a nitric oxide-releasing prodrug of Naproxen (HY-15030). NMI-1182 is an orally active COX-1 and COX-2 inhibitor. NMI-1182 inhibits constitutive COX-1-mediated and inducible COX-2-mediated prostaglandin synthesis. NMI-1182 induces nitric oxide donor release, activating soluble guanylate cyclase to synthesize cGMP, causing vasodilation. NMI-1182 can be used for research on inflammation and pain.

For research use only. We do not sell to patients.

CAS No.: 646509-43-5
Formula: C₁₇H₁₈N₂O₉
Molecular Weight:394.33

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

NMI-1182 Chemical Structure

CAS No.: 646509-43-5

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
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Classifications
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Biological Activity

Description

IC₅₀ & Target

^[1]^[2]

COX-1

COX-2

All COX Isoforms :

In Vitro

Local Vascular RegulationInnate ImmunityLipid Inflammatory Mediators

Local Vascular Regulation

NMI-1182 inhibits COX-1 and COX-2 in human whole blood^[1].
NMI-1182 is a potent NO donor in LLC-PK1 cells, inducing cGMP at concentrations as low as 3 nM^[1].
NMI-1182 inhibits COX-1 and COX-2 activity in human whole blood, with −log IC₅₀ values of 4.71 and 5.05 for COX-1 and COX-2, respectively^[2].

Innate Immunity

NMI-1182 (70 μM; 15 min) induces cGMP synthesis in human hepatocytes^[1].

Lipid Inflammatory Mediators

Local Vascular Regulation

NMI-1182 (1 nM-10 µM) produces concentration-dependent vasodilation in isolated rat aorta^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Innate ImmunityLipid Inflammatory Mediators

Innate Immunity

NMI-1182 (10 mg/kg; oral; single administration 1 h before Carrageenan (HY-125474)) exhibited anti-inflammatory activity in Carrageenan-induced paw edema rats^[2].

Lipid Inflammatory Mediators

Innate Immunity

NMI-1182 (5 mg/kg; oral; single administration 1 h before Carrageenan injection) significantly reduced leukocyte infiltration and decreased PGE₂ levels by 90% in Carrageenan-induced air pouch inflammation rats^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Sprague-Dawley rats (Male, 180-220 g, fasted)^[2]
Dosage:

10 mg/kg
Administration:

p.o.; single dose 1 h prior to Carrageenan
Result:

Showed comparable inhibition of paw oedema of between 50 and 65% at 3 h post-insult.

Animal Model:

Sprague-Dawley rats (Male, 180-220 g)^[2]
Dosage:

5 mg/kg
Administration:

p.o.; single dose 1 h prior to Carrageenan
Result:

Significantly reduced Carrageenan-induced leukocyte influx.
Significantly reduced PGE₂ levels in the exudates by 90%.

Related Protocols :

Research Protocol for Inflammation-related Diseases

Chemical Information

CAS No. 646509-43-5
Molecular Weight 394.33
Formula C₁₇H₁₈N₂O₉
SMILES

O=C(OC[C@@H](O[N+]([O-])=O)CO[N+]([O-])=O)[C@H](C1=CC2=C(C=C1)C=C(C=C2)OC)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Young DV, et al. A comparison of the cyclooxygenase inhibitor-NO donors (CINOD), NMI-1182 and AZD3582, using in vitro biochemical and pharmacological methods. Biochemical pharmacology. 2005 Nov 01;70(9):1343-51.

[2]. Ellis JL, et al. NMI-1182, a gastro-protective cyclo-oxygenase-inhibiting nitric oxide donor. Inflammopharmacology. 2005;12(5-6):521-34.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References

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NMI-1182

All COX Isoforms