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Cat. No.: HY-184472

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NOD1 agonist-1

NOD1 agonist-1 is a NOD1 agonist with immunostimulatory and adjuvant activities. NOD1 agonist-1 enhances ovalbumin-specific total IgG antibody responses in mouse vaccination models. NOD1 agonist-1 can be used for the research of immune-related diseases.

For research use only. We do not sell to patients.

Formula: C₂₉H₅₄N₄O₈
Molecular Weight:586.76

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

NOD1 agonist-1 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
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Classifications
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Biological Activity

Description

IC₅₀ & Target

^[1]

NOD1

All NOD-like Receptor (NLR) Isoforms :

In Vitro

Innate Immunity

NOD1 agonist-1 (0.005, 0.078, 1.25, 20 μM; 18 h) activates NOD1 in HEK-Blue hNOD1 cells in a concentration-dependent manner, with maximal activity at 20 μM after 18 h of incubation^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Innate ImmunityAdaptive Immunity

Innate Immunity

Adaptive Immunity

NOD1 agonist-1 (50 μg; subcutaneous injection; administered on days 0-42) acts as an effective vaccine adjuvant in mice, and the OVA-specific total IgG titer it induces is higher than that of OVA without adjuvant or alum^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

NIH/OlaHsd (female, 2.0−2.5 months old)^[1]
Dosage:

50 μg
Administration:

s.c.; on days 0, 21, and 42
Result:

Induced stronger OVA-specific total IgG responses than unadjuvanted OVA or alum (100 μg).
Did not substantially alter the relative distribution of anti-OVA IgG1 and IgG2a antibody isotypes.

Chemical Information

Molecular Weight 586.76
Formula C₂₉H₅₄N₄O₈
SMILES

O=C(OCC)C(N)CCCC(NC(CC[C@@H](NC(CCCCCCCCCCCN)=O)C(OC)=O)=O)C(OCC)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Emiliano Paradiso, et al. Conjugated NOD1-Centered Dual Agonists Exhibit Modest In Vitro Immunomodulation but Potent In Vivo Adjuvanticity.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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