NOD1 antagonist-1
Based on 1 Customer Validation
NOD1 antagonist-1 (compound 37) exhibits an antagonistic activity towards NOD1 and a weak NOD1/NOD2 selectivity, with IC50s of 9.18 μM and 20.8 μM, respectively.
For research use only. We do not sell to patients.
- Purity : 99.85%
- CAS No.: 3030588-37-2
- Formula: C24H32N4O2S
- Molecular Weight:440.60
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
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NOD1 9.18 μM (IC50) |
NOD2 20.8 μM (IC50) |
In Vitro
NOD1 antagonist-1 (25 μM, 1 h) inhibits the NF-kB transcriptional activation in HEK-Blue cells with low cytotoxicity (25 μM, 18 h)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HEK-Blue
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Concentration:25 μM
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Incubation Time:18 h
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Result:Maintained a residual metabolic activity of over 80%.
Chemical Information
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CAS No. 3030588-37-2
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Appearance Solid
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Molecular Weight 440.60
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Formula C24H32N4O2S
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Color Off-white to light yellow
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SMILES
CC1=CC=C(S(N2C3=CC=CC=C3C(N4CCN(CC4)C)=C2NC(C)(C)C)(=O)=O)C=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
In Vitro:
DMSO : 33.33 mg/mL (75.65 mM; Need warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (276 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.2696 mL | 11.3482 mL | 22.6963 mL | 56.7408 mL |
| 5 mM | 0.4539 mL | 2.2696 mL | 4.5393 mL | 11.3482 mL | |
| 10 mM | 0.2270 mL | 1.1348 mL | 2.2696 mL | 5.6741 mL | |
| 15 mM | 0.1513 mL | 0.7565 mL | 1.5131 mL | 3.7827 mL | |
| 20 mM | 0.1135 mL | 0.5674 mL | 1.1348 mL | 2.8370 mL | |
| 25 mM | 0.0908 mL | 0.4539 mL | 0.9079 mL | 2.2696 mL | |
| 30 mM | 0.0757 mL | 0.3783 mL | 0.7565 mL | 1.8914 mL | |
| 40 mM | 0.0567 mL | 0.2837 mL | 0.5674 mL | 1.4185 mL | |
| 50 mM | 0.0454 mL | 0.2270 mL | 0.4539 mL | 1.1348 mL | |
| 60 mM | 0.0378 mL | 0.1891 mL | 0.3783 mL | 0.9457 mL |
NOD1 antagonist-1 Related Classifications
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