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Cat. No.: HY-189822

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Nrf2 ligand-3

Nrf2 ligand-3 (Compound 11) is an Nrf2 ligand with an A51-derived scaffold. Nrf2 ligand-3 can serve as a PROTAC target protein ligand for the synthesis of L013 (HY-210438).

For research use only. We do not sell to patients.

CAS No.: 2680526-02-5
Formula: C₂₁H₂₇ClN₆
Molecular Weight:398.93

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Nrf2 ligand-3 Chemical Structure

CAS No.: 2680526-02-5

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

Nrf2 ligand-3 (Compound 11) is an Nrf2 ligand with an A51-derived scaffold. Nrf2 ligand-3 can serve as a PROTAC target protein ligand for the synthesis of L013 (HY-210438)^[1].

IC₅₀ & Target

^[1]

Nrf2

In Vitro

PROTAC, short for proteolysis-targeting chimeras, is a heterobifunctional small-molecule compound containing two different ligands: one is a ubiquitin ligase E3 ligand, and the other is a ligand that binds to the target protein in cells. The two ligands are connected by a linker, thereby forming a "ternary" polymer-target protein ligand-Linker-E3 ligand. PROTACs specifically degrade target proteins through the "ubiquitin-proteasome" pathway by bringing the target protein and the intracellular E3 ubiquitin ligase into close proximity. PROTACs can improve the druggability of "undruggable" targets.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2680526-02-5
Molecular Weight 398.93
Formula C₂₁H₂₇ClN₆
SMILES

CN(N=C1)C(CC2CC2)=C1C3=NC(N[C@H](CC4)CC[C@@H]4NCC#C)=NC=C3Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Yu X, et al. L013 promotes NRF2 degradation in NRFA-subtype esophageal squamous cell carcinoma. Cell reports. Medicine. 2026 Sep 11.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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