NRL-1049 dihydrochloride
Based on 1 Customer Validation
NRL-1049 dihydrochloride (BA-1049) is a selective and orally active rho-associated protein kinase 2 (ROCK2) inhibitor with an IC50 of 0.59 μM. NRL-1049 dihydrochloride shows selectivity for ROCK2 is 44 times that of ROCK1 (IC50 = 26 μM). NRL-1049 dihydrochloride can preserve the blood-brain barrier after acute injury.
For research use only. We do not sell to patients.
- Purity : 99.32%
- CAS No.: 1973494-17-5
- Formula: C16H23Cl2N3O2S
- Molecular Weight:392.34
-
Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
-
Solvent & Solubility
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
Description
Chemical Information
-
CAS No. 1973494-17-5
-
Appearance Solid
-
Molecular Weight 392.34
-
Formula C16H23Cl2N3O2S
-
Color White to yellow
-
SMILES
C[C@H](C1CCN(CC1)S(=O)(C2=C3C=CN=CC3=CC=C2)=O)N.Cl.Cl
-
Synonyms
BA-1049
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
In Vitro:
DMSO : 100 mg/mL (254.88 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : 50 mg/mL (127.44 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
-
Data Sheet (274 KB)
-
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
-
Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O / DMSO | 1 mM | 2.5488 mL | 12.7440 mL | 25.4881 mL | 63.7202 mL |
| 5 mM | 0.5098 mL | 2.5488 mL | 5.0976 mL | 12.7440 mL | |
| 10 mM | 0.2549 mL | 1.2744 mL | 2.5488 mL | 6.3720 mL | |
| 15 mM | 0.1699 mL | 0.8496 mL | 1.6992 mL | 4.2480 mL | |
| 20 mM | 0.1274 mL | 0.6372 mL | 1.2744 mL | 3.1860 mL | |
| 25 mM | 0.1020 mL | 0.5098 mL | 1.0195 mL | 2.5488 mL | |
| 30 mM | 0.0850 mL | 0.4248 mL | 0.8496 mL | 2.1240 mL | |
| 40 mM | 0.0637 mL | 0.3186 mL | 0.6372 mL | 1.5930 mL | |
| 50 mM | 0.0510 mL | 0.2549 mL | 0.5098 mL | 1.2744 mL | |
| 60 mM | 0.0425 mL | 0.2124 mL | 0.4248 mL | 1.0620 mL | |
| 80 mM | 0.0319 mL | 0.1593 mL | 0.3186 mL | 0.7965 mL | |
| 100 mM | 0.0255 mL | 0.1274 mL | 0.2549 mL | 0.6372 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
NRL-1049 dihydrochloride Related Classifications
HY-126432 Related Classifications
Powered by Bioz