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Cat. No.: HY-189132

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NSC-2488 hydrochloride

NSC-2488 hydrochloride is a ROCK-II inhibitor with an IC₅₀ of 8.02 nM. NSC-2488 hydrochloride inhibits ROCK-II enzyme activity, blocks MYPT1 phosphorylation, and induces vascular smooth muscle relaxation. NSC-2488 hydrochloride can be used for research on hypertension.

For research use only. We do not sell to patients.

CAS No.: 5459-61-0
Formula: C₁₅H₂₂Cl₂N₂O₂
Molecular Weight:333.25

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

NSC-2488 hydrochloride Chemical Structure

CAS No.: 5459-61-0

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
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Biological Activity

Description

IC₅₀ & Target

^[1]

ROCK-II

8.02 nM (IC₅₀)

All ROCK Isoforms :

In Vitro

NSC-2488 hydrochloride is a potent Rho-kinase inhibitor with an IC₅₀ of 8.02 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Chemical Information

CAS No. 5459-61-0
Molecular Weight 333.25
Formula C₁₅H₂₂Cl₂N₂O₂
SMILES

OC(CC)CNCC1=C2C=C(OC)C=CC2=NC=C1.Cl.Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Kesar S, et al. Identification of Novel Rho-Kinase-II Inhibitors with Vasodilatory Activity. ACS medicinal chemistry letters. 2020 Sep 10;11(9):1694-1703. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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