NSC 852426

NSC 852426 is a PDGFRα/VEGFR-2 inhibitor with IC50 values of 1.179 μM and 1.818 μM, respectively. NSC 852426 inhibits AKT and ERK1/2 phosphorylation, upregulates P53, BAX, and caspase-3 while inhibiting Bcl-2, and induces intrinsic mitochondrial apoptosis. NSC 852426 exhibits selective antiproliferative and cytotoxic effects against multiple cancer cell lines, and shows moderate selectivity for leukemia and colon cancer subgroups. NSC 852426 can be used in cancer-related research, such as leukemia and colon cancer.

For research use only. We do not sell to patients.

  • Formula: C22H17N3O4
  • Molecular Weight:387.39
  • Storage:

    Please store the product under the recommended conditions in the Certificate of Analysis.

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