country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-188256

Copy Link Print Information

NSC66098

NSC66098 is an RNA-binding agent. NSC66098 binds to expanded CAG repeat RNA containing AA mismatches and inhibits its pathogenic function. NSC66098 protects cells from proteotoxicity induced by polyglutamine aggregates. NSC66098 can be used in research on Huntington's disease and spinocerebellar ataxia.

For research use only. We do not sell to patients.

CAS No.: 3259-43-6
Formula: C₁₅H₁₁FN₂S
Molecular Weight:270.32

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

NSC66098 Chemical Structure

CAS No.: 3259-43-6

Price

Stock

Quantity

Amount: USD 0.00

* Please select Quantity before adding items.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

All DNA/RNA Synthesis Isoforms :

In Vitro

NSC66098 binds (5′CAG/3′GAC) x6 RNA with nanomolar affinity in ITC and discriminates against the control 5′CAG/3′GUC duplex RNA with micromolar affinity^[1].
NSC66098 selectively blocks (5′CAG/3′GAC) RNA and inhibits PCR amplification of CAG-repeat DNA, without comparable effects on controls^[1].
NSC66098 protects Cos-7 cells from proteotoxicity induced by polyglutamine aggregates^[1].
NSC66098 (24 h) reduces Thioflavin T fluorescence of protein aggregates in HD-derived GM04281 fibroblasts in a concentration-dependent manner^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 3259-43-6
Molecular Weight 270.32
Formula C₁₅H₁₁FN₂S
SMILES

FC1=CC=C2N=NC=C(C2=C1)SCC3=CC=CC=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Khan E, et al. Discovery of a potent small molecule inhibiting Huntington's disease (HD) pathogenesis via targeting CAG repeats RNA and Poly Q protein. Scientific reports. 2019 Nov 14;9(1):16872.

Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

Get Quote In-stock

Other size

Get Quote