Nurr1 agonist-15
Nurr1 agonist-15 is a Nurr1 agonist that activates Nurr1-mediated transcription. Nurr1 agonist-15 acts as a RXRα agonist and a PPARγ agonist, activates RXRα- and PPARγ-mediated transcription, and exhibits preference for Nurr1 among NR4A receptors. Nurr1 agonist-15 has potential for research on neurological diseases and inflammatory immune diseases.
For research use only. We do not sell to patients.
- CAS No.: 1039850-23-1
- Formula: C15H11F3O3
- Molecular Weight:296.24
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All Nuclear Hormone Receptor 4A/NR4A Isoforms
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Biological Activity
Description
IC50 & Target
[1]|
Nurr1/NR4A2 |
RXR α |
PPARγ |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HEK-293T | EC50 |
7.0 μM
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Activation of Nurr1 in transiently transfected HEK293T cells by Gal4-hybrid reporter gene assay measured by luciferase activity after 16 hrs incubation.
Activation of Nurr1 in transiently transfected HEK293T cells by Gal4-hybrid reporter gene assay measured by luciferase activity after 16 hrs incubation.
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37918435 |
In Vitro
Nurr1 agonist-15 (16 h) activates Nurr1 in a Gal4 hybrid reporter gene assay with an EC50 of 7.0 μM and a maximum activation rate of 305%, demonstrating preference for Nurr1[1].
Nurr1 agonist-15 (30 μM; 16 h) exhibits significant RXRα agonism and slight PPARγ activation in selectivity assays[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1039850-23-1
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Molecular Weight 296.24
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Formula C15H11F3O3
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SMILES
O=C(C1=CC(OCC2=CC=CC(C(F)(F)F)=C2)=CC=C1)O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Nurr1 agonist-15 Related Classifications
HY-187970 Related Classifications
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