Olsalazine-d6
Based on 1 Customer Validation
Olsalazine-d6 is the deuterium labeled Olsalazine (HY-B0174A). Olsalazine is an orally active prodrug of 5-ASA (HY-15027). Olsalazine can inhibit cells proliferation and induce apoptosis. Olsalazine can reduce DAI and MPO activity and inhibit inflammatory cytokines levels. Olsalazine can be used for the researches of cancer, inflammation and metabolic disease, such as colorectal cancer, inflammatory bowel disease (IBD) and hyperuricemic.
For research use only. We do not sell to patients.
- Purity : 95.93%
- Formula: C14H4D6N2O6
- Molecular Weight:308.28
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Storage:
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Protocols
- Purity & Documentation
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Help & FAQs
Biological Activity
Description
In Vitro
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
- Detection of Apoptosis
- TUNEL staining for apoptotic DNA fragmentation
- LPS-Induced Endotoxemia/Systemic Inflammation
- Annexin V plus membrane-impermeant dye apoptosis staining
- DSS-Induced Colitis
- TNBS-Induced Colitis
- Apoptosis Solutions
- Research Protocol for Inflammation-related Diseases
- Research Protocol for Metabolic Diseases
- Cell Viability Determination by MTT Colorimetric Assay
Application
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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Unlabeled CAS 15722-48-2
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Appearance Solid
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Molecular Weight 308.28
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Formula C14H4D6N2O6
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Color Yellow to brown
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SMILES
O=C(O)C1=C(O)C([2H])=C([2H])C(/N=N/C2=C([2H])C(C(O)=O)=C(O)C([2H])=C2[2H])=C1[2H]
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
In Vitro:
DMSO : 12.5 mg/mL (40.55 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (244 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.2438 mL | 16.2190 mL | 32.4380 mL | 81.0951 mL |
| 5 mM | 0.6488 mL | 3.2438 mL | 6.4876 mL | 16.2190 mL | |
| 10 mM | 0.3244 mL | 1.6219 mL | 3.2438 mL | 8.1095 mL | |
| 15 mM | 0.2163 mL | 1.0813 mL | 2.1625 mL | 5.4063 mL | |
| 20 mM | 0.1622 mL | 0.8110 mL | 1.6219 mL | 4.0548 mL | |
| 25 mM | 0.1298 mL | 0.6488 mL | 1.2975 mL | 3.2438 mL | |
| 30 mM | 0.1081 mL | 0.5406 mL | 1.0813 mL | 2.7032 mL | |
| 40 mM | 0.0811 mL | 0.4055 mL | 0.8110 mL | 2.0274 mL |
Olsalazine-d6 Related Classifications
HY-B0174AS3 Related Classifications
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