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Onartuzumab

(Synonyms: MetMAb)
2 Cited Publications
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Based on 2 publication(s) in Google Scholar

Onartuzumab (MetMAb) is a unique, humanized and affinity-matured monovalent (one-armed) monoclonal antibody against the MET receptor. Onartuzumab potently inhibits HGF binding and receptor phosphorylation and signaling. Onartuzumab has antibody-like pharmacokinetics and antitumor activity.

For research use only. We do not sell to patients.

  • Purity : 99.62%
  • CAS No.: 1133766-06-9
  • Molecular Weight:98.907 kDa
  • Storage:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Experimental Validation Results for Onartuzumab
  • Experimental Validation Results for Onartuzumab
  • Experimental Validation Results for Onartuzumab
  • Experimental Validation Results for Onartuzumab
  • Experimental Validation Results for Onartuzumab
  • Onartuzumab Chemical Structure
    Onartuzumab Chemical Structure
CAS No.: 1133766-06-9
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Onartuzumab Product Recommendations:

To place orders, for customer services and technical support, please contact:

609-228-6898
[email protected] [email protected]
Find Your Local Distributor Your local distributor: Hycultec GmbHHycultec
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Top Publications Citing

Use of MCE Products

Publications Citing Use of MedChemExpress (MCE) Onartuzumab

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Cell Proliferation/Viability AssayCell Migration/Invasion Assay
  • Cell Proliferation/Viability Assay
  • Cell Migration/Invasion Assay

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Assay Types
  • 1/16

    (Fab-G1-kappa)-(Fc-G1)

  • 1/16

    Immobilized Onartuzumab can bind Human c-MET/HGFR Protein (ECD, His Tag). The EC50 for this effect is 4.21 ng/mL.

  • 1/16

    Flow cytometric analysis of 1.5×106 MDA-MB-231 cells with Onartuzumab (HY-P99250, red). Cells were fixed with 4% paraformaldehyde. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa Isotype Control (HY-P99001, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).

  • 1/16

    Onartuzumab purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2026 Mar 20:e16557. [Abstract]

    Customer Validation
     A CCK-8 proliferation assay was used to assess the proliferation of HCT116 and DLD-1 cells; these cells were seeded in the lower chambers of Transwell inserts and co-cultured with LX-2 cells placed in the upper chambers. The MET-blocking antibody Onartuzumab (10 µg/mL) was added to evaluate the role of the MET signaling pathway.

  • 1/16

    Onartuzumab purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2026 Mar 20:e16557. [Abstract]

    Customer Validation
     Transwell migration assays were used to evaluate the chemotactic migration of HCT116 and DLD-1 cells toward LX-2 cells seeded in the lower chamber. Onartuzumab (10 µg/mL) was used to block the MET signaling pathway. Representative images are shown.

  • Onartuzumab Chemical Structure
    1/16
  • Onartuzumab
  • Immobilized Onartuzumab can bind Human c-MET/HGFR Protein (ECD, His Tag). The EC50 for this effect is 4.21 ng/mL.
  • Flow cytometric analysis of 1.5×106 MDA-MB-231 cells with Onartuzumab (HY-P99250, red). Cells were fixed with 4% paraformaldehyde. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa Isotype Control (HY-P99001, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).
  • (Fab-G1-kappa)-(Fc-G1)