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Cat. No.: HY-165568

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OPC 3911

OPC 3911 is a highly selective inhibitor of cGMP-inhibited cAMP phosphodiesterase (cGI-PDE/PDE3) and a vasodilator, with an IC₅₀ of 0.042 μM against rat cGI-PDE. OPC 3911 upregulates the expression of Osteopontin. OPC 3911 mediates vasodilation of arterial smooth muscle, induces vasodilatory responses in isolated rat arteriovenous tissues, and exhibits additive vasodilatory effects with Isoprenaline (HY-108353) and Forskolin (HY-15371). OPC 3911 can be used in studies related to congestive heart failure and insulin resistance.

For research use only. We do not sell to patients.

CAS No.: 76470-87-6
Formula: C₂₁H₃₀N₂O₄
Molecular Weight:374.48

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Please store the product under the recommended conditions in the Certificate of Analysis.

OPC 3911 Chemical Structure

CAS No.: 76470-87-6

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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Biological Activity

Description

IC₅₀ & Target

^[2]

PDE3

42 nM (IC₅₀)

All Phosphodiesterase (PDE) Isoforms :

In Vitro

Local Vascular RegulationLipid Inflammatory MediatorsOthers

Local Vascular Regulation

OPC 3911 (up to 30 μM) induces concentration-dependent relaxation of coronary and renal arteries pre-contracted with 30 mM K⁺, with EC₅₀ values of 1.4 μM and 0.87 μM, respectively; however, at the dose of 30 μM, it only induces 42% relaxation of pulmonary arteries pre-contracted with 30 mM K⁺^[1].

Local Vascular Regulation

Lipid Inflammatory Mediators

OPC 3911 exerts concentration-dependent relaxation effects on agonist-contracted coronary arteries (EC₅₀ = 0.54 μM), pulmonary arteries (EC₅₀ = 0.39 μM), and renal arteries (EC₅₀ = 0.83 μM)^[1].

Local Vascular Regulation

OPC 3911 (up to 10 μM) potently relaxes mesenteric arterial segments contracted by Norepinephrine (HY-13715), with an EC₅₀ of 0.51 μM and a maximum relaxation amplitude of 58%^[2].

Others

OPC 3911 potently inhibits the cGMP-inhibited low K_m cAMP phosphodiesterase purified from rat adipose tissue, with an IC₅₀ of 0.042 μM^[2].

Others

OPC 3911 (10 µM) significantly upregulates the protein expression level of osteopontin in primary rat adipocytes^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

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Chemical Information

CAS No. 76470-87-6
Molecular Weight 374.48
Formula C₂₁H₃₀N₂O₄
SMILES

O=C1NC2=CC=C(OCCCC(=O)N(CCO)C3CCCCC3)C=C2CC1
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Lindgren S, et al. Effects of selective phosphodiesterase inhibitors on isolated coronary, lung and renal arteries from man and rat. Acta physiologica Scandinavica. 1991 May;142(1):77-82. [Content Brief]

[2]. Lindgren S, et al. Relaxant effects of the selective phosphodiesterase inhibitors milrinone and OPC 3911 on isolated human mesenteric vessels. Pharmacology & toxicology. 1989 May;64(5):440-5. [Content Brief]

[3]. Omar B, et al. Regulation of the pro-inflammatory cytokine osteopontin by GIP in adipocytes--a role for the transcription factor NFAT and phosphodiesterase 3B. Biochem Biophys Res Commun. 2012 Sep 7;425(4):812-7. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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OPC 3911

All Phosphodiesterase (PDE) Isoforms

Biological Activity

Description

IC50 & Target

In Vitro

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

OPC 3911 Related Classifications

HY-165568 Related Classifications

Bioz

Keywords

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