p53 Activator 16
Based on 1 publication(s) in Google Scholar
P53 Activator 16 (Compound JC16) is a p53 activator. P53 Activator 16 exhibits selective cytotoxicity and pro-apoptotic (apoptosis) activity towards p53-Y220C mutant cancer cells, while having little effect on wild-type or P53-deficient cells. P53 Activator 16 induces the conformational transition of cell p53-Y220C from the mutant form to the wild-type form, accompanied by the transcriptional activation of p53 target genes, without increasing the overall level of p53 protein. P53 Activator 16 can be used for the study of p53 mutant cancers.
For research use only. We do not sell to patients.
- Formula: C15H17N5O2
- Molecular Weight:299.33
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
Description
Chemical Information
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Molecular Weight 299.33
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Formula C15H17N5O2
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SMILES
CN(C)CCN1N=C(N2C=CC=C2)C3=CC([N+]([O-])=O)=CC=C31
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Purity & Documentation
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Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
p53 Activator 16 Related Classifications
HY-179506 Related Classifications
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