Paclitaxel-13C6
Paclitaxel-13C6 is the 13C-labeled Paclitaxel. Paclitaxel is a naturally occurring antineoplastic agent and stabilizes?tubulin?polymerization. Paclitaxel can cause both mitotic arrest and?apoptotic?cell death. Paclitaxel also induces?autophagy.
For research use only. We do not sell to patients.
- Formula: C4113C6H51NO14
- Molecular Weight:859.86
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
In Vitro
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Application
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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Appearance Solid
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Molecular Weight 859.86
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Formula C4113C6H51NO14
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Color White to off-white
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SMILES
O=C([C@]1([C@@H]([C@@H]([C@@]2(C[C@@H](C(C)=C3C2(C)C)OC([C@H]([C@@H](C4=CC=CC=C4)NC(C5=CC=CC=C5)=O)O)=O)O)OC([13C]6=[13C]([13C]([H])=[13C]([13C]([H])=[13C]6[H])[H])[H])=O)[C@]7(OC(C)=O)CO[C@@H]7C[C@@H]1O)C)[C@@H]3OC(C)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Purity & Documentation
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Data Sheet (281 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Choi YH, et al. Paclitaxel-induced growth arrest and apoptosis is associated with the upregulation of the Cdk inhibitor, p21WAF1/CIP1, in human breast cancer cells. Oncol Rep. 2012 Dec;28(6):2163-9. [Content Brief]
[2]. Dziadyk JM, et al. Paclitaxel-induced apoptosis may occur without a prior G2/M-phase arrest. Anticancer Res. 2004 Jan-Feb;24(1):27-36. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Paclitaxel-13C6 Related Classifications
HY-W768912 Related Classifications
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