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Palverafusp alfa

(Synonyms: IMM-2510; SYN-2510)
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Based on 1 Customer Validation

Palverafusp alfa (IMM-2510; SYN-2510) is a PD-L1/VEGF-targeting IgG1κ type humanized antibody. Palverafusp alfa blocks PD-1/PD-L1 binding, relieves immune suppression, mediates PD-L1-directed antibody-dependent cellular cytotoxicity (ADCC). Palverafusp alfa blocks VEGF/VEGFR binding, inhibits angiogenic signaling, relieves VEGF-induced immune suppression. Palverafusp alfa reduces endothelial cell proliferation, enhances ADCC and antibody-dependent cellular phagocytosis (ADCP), inhibits tumor growth, reverses T cell immune suppression. Palverafusp alfa exhibits immune stimulatory, antiangiogenic, and anti-tumor activity in the tumor microenvironment. Palverafusp alfa can be used for the research of cancer, such as solid tumors, non-small cell lung cancer.

For research use only. We do not sell to patients.

  • Purity : 98.00%
  • CAS No.: 2850355-87-0
  • Molecular Weight:169.11 kDa
  • Storage:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Experimental Validation Results for Palverafusp alfa
  • Experimental Validation Results for Palverafusp alfa
  • Palverafusp alfa Chemical Structure
    Palverafusp alfa Chemical Structure
CAS No.: 2850355-87-0
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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Palverafusp alfa Product Recommendations:

To place orders, for customer services and technical support, please contact:

609-228-6898
[email protected] [email protected]
Find Your Local Distributor Your local distributor: Hycultec GmbHHycultec
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Top Publications Citing

Use of MCE Products

All VEGFR Isoforms

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Assay Types
  • 1/16

    IgG1-kappa-[PROTEIN]2-in-VH

  • 1/16

    Loaded Palverafusp alfa on AHC2 biosensor, can bind VEGF121 Protein, Human (HEK293, His, HY-P70519) with an affinity constant of 2.310E-10 M as determined in BLI assay.

  • Palverafusp alfa Chemical Structure
    1/16
  • Palverafusp alfa
  • Loaded Palverafusp alfa on AHC2 biosensor, can bind VEGF121 Protein, Human (HEK293, His, HY-P70519) with an affinity constant of 2.310E-10 M as determined in BLI assay.
  • IgG1-kappa-[PROTEIN]2-in-VH