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Pamiparib maleate

(Synonyms: BGB-290 maleate)
3 Cited Publications
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Based on 3 publication(s) in Google Scholar

Pamiparib maleate (BGB-290 maleate) is a highly potent and selective PARP inhibitor with neurotoxicity-inducing activity. Pamiparib maleate can effectively penetrate the blood-brain barrier and cause cerebral hemorrhage, brain atrophy, and movement disorders in zebrafish embryos exposed. Pamiparib maleate exposure downregulates the activities of acetylcholinesterase (AChE) and adenosine triphosphatase (ATPase) and leads to upregulation of oxidative stress, which triggers apoptosis and interferes with the expression of neurodevelopment-related genes. The use of pamiparib maleate is also accompanied by downregulation of the Notch signaling pathway, while activation of the Notch signaling pathway can partially rescue neurodevelopmental toxicity. Therefore, pamiparib maleate provides a reference for evaluating its potential neurotoxicity during embryonic development.

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  • CAS No.: 2086689-94-1
  • Formula: C16H15FN4O.3/2C4H4O4
  • Molecular Weight:944.85
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    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Pamiparib maleate Chemical Structure
    Pamiparib maleate Chemical Structure
  • Experimental Validation Results for Pamiparib maleate
  • Experimental Validation Results for Pamiparib maleate
CAS No.: 2086689-94-1
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  • Pamiparib maleate Chemical Structure
    Pamiparib maleate Chemical Structure
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    Pamiparib maleate purchased from MedChemExpress. Usage Cited in: bioRxiv. April 22, 2021.

    Customer Validation
     Acetyl-α-tubulin and phospho-histone 3 immunostaining of Daoy cells treated with either vehicle control, 6.25 μM BGB 290 (Pamiparib), 1.7 nM romidepsin or 6.25 μM BGB-290 with 1.7 nM romidepsin for 48 hours.

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    Pamiparib maleate purchased from MedChemExpress. Usage Cited in: Nature. 2019 Dec;576(7786):274-280. [Abstract]

    Customer Validation
     Dose response curves of ETMR cells treated with Pamiparib (0-100 μM).

  • Pamiparib maleate