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Cat. No.: HY-187469

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PARP1-IN-59

PARP1-IN-59 is a PARP1 inhibitor and can be used in research on PARP1-mediated related diseases, such as cancer.

For research use only. We do not sell to patients.

CAS No.: 2982276-33-3
Formula: C₂₃H₂₃F₂N₅O₃
Molecular Weight:455.46

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

PARP1-IN-59 Chemical Structure

CAS No.: 2982276-33-3

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
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- IC₅₀ & Target
- In Vitro
Chemical Information
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Biological Activity

Description

PARP1-IN-59 is a PARP1 inhibitor and can be used in research on PARP1-mediated related diseases, such as cancer^[1].

IC₅₀ & Target

^[1]

PARP-1

All PARP Isoforms :

In Vitro

PARP1-IN-59 (Example 83) is obtained through a series of reactions starting from (2-ethoxycarbonyl) furan-3-ylboronic acid and methyl 4-bromo-3-fluoro-5-nitrobenzoate^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2982276-33-3
Molecular Weight 455.46
Formula C₂₃H₂₃F₂N₅O₃
SMILES

FC1=C(CN2CCN(C3=C(F)N=C(C(NC)=O)C=C3)CC2)C=CC4=C1NC(C5=C4OCC5)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Cai S X, et al. Substituted tricyclic compounds as parp inhibitors and the use thereof. WIPO, 2023, WO2023169226A1.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
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- In Vitro
Chemical Information
Purity & Documentation
References

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PARP1-IN-59

All PARP Isoforms

Biological Activity

Description

IC50 & Target

In Vitro

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

PARP1-IN-59 Related Classifications

HY-187469 Related Classifications

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