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Cat. No.: HY-157293

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PBI4600

PBI4600 is a quinone-trimethyl-locked coelenterazine-based proluminescent substrate and a probe for detecting the redox status and viability of metabolically active cells. PBI4600 releases the coelenterazine reporter group upon reduction by metabolically active cells, generating a luminescent signal through the bioluminescence system, with signal intensity correlating with cellular redox status and metabolic activity. PBI4600 can be used for research related to the redox status and viability of living cells.

For research use only. We do not sell to patients.

CAS No.: 1374040-22-8
Formula: C₄₃H₄₅N₅O₆
Molecular Weight:727.86

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

PBI4600 Chemical Structure

CAS No.: 1374040-22-8

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
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Biological Activity

Description

In Vitro

PBI4600 (30 min) shows a linear positive correlation between luminescence signal (RLU) and the number of seeded cells in Jurkat cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Chemical Information

CAS No. 1374040-22-8
Molecular Weight 727.86
Formula C₄₃H₄₅N₅O₆
SMILES

O=C(OC1=C(N=C2C(=NC(=CN21)C=3C=CC=CC3)CC=4C=CC=CC4)CC=5OC=CC5)N(C)CCN(C(=O)CC(C=6C(=O)C(=C(C(=O)C6C)C)C)(C)C)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Benink H, et al. Compounds and Methods for Assaying Redox State of Metabolically Active Cells and Methods for Measuring NAD(P)/NAD(P)H. WO 2013/033515 A1.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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