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Cat. No.: HY-175901A

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PD-1 ligand-2

PD-1 ligand-2 is a target protein ligand-linker conjugate that can be used in studies related to PROTAC synthesis, such as serving as the target protein ligand-linker conjugate for (Rac)-EBET-1055 (HY-161346A).

For research use only. We do not sell to patients.

Formula: C₃₈H₄₆N₆O₅
Molecular Weight:666.81

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

PD-1 ligand-2 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
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Biological Activity

Description

In Vitro

PD-1 ligand-2 serves as a target protein ligand-linker conjugate for (Rac)-EBET-1055 (HY-161346A), which is the racemate of EBET-1055 (HY-161346). EBET-1055 is a bromodomain and extra-terminal (BET) PROTAC degrader that inhibits the growth of pancreatic ductal adenocarcinoma (PDAC)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Molecular Weight 666.81
Formula C₃₈H₄₆N₆O₅
SMILES

OCC(OC1CC1)(C2=CC=CC=C2)C3=NC(N4CCC(CN5CCN(C(CO)=O)CC5)CC4)=NC6=CC=C(C(C=C7C)=CN(C)C7=O)C=C63
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Nakazawa Y, et al. Delivery of a BET protein degrader via a CEACAM6-targeted antibody-drug conjugate inhibits tumour growth in pancreatic cancer models. Nature communications. 2024 Mar 11;15(1):2192. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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