country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-190133

Copy Link Print Information

PD-L1 antagonist-1

PD-L1 antagonist-1 is a PD-L1 antagonist. PD-L1 antagonist-1 induces PD-L1 dimerization/oligomerization and blocks the PD-1/PD-L1 interaction with an IC₅₀ of 254 nM. PD-L1 antagonist-1 can be used in research related to neurological diseases.

For research use only. We do not sell to patients.

CAS No.: 3123326-31-5
Formula: C₂₃H₂₇N₅O₃
Molecular Weight:421.49

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

PD-L1 antagonist-1 Chemical Structure

CAS No.: 3123326-31-5

Price

Stock

Quantity

Amount: USD 0.00

* Please select Quantity before adding items.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

In Vitro

PD-L1 antagonist-1 (compound 10p) inhibits the PD-1/PD-L1 complex in the HTRF assay (IC₅₀ = 254 nM)^[1].
PD-L1 antagonist-1 (protein:inhibitor molar ratio 1:1) induces hPD-L1 oligomerization in ¹H NMR titration^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 3123326-31-5
Molecular Weight 421.49
Formula C₂₃H₂₇N₅O₃
SMILES

OCCCNC(C1=NN=NN1/C=C/C2=C(C)C(C(C=C3)=CC4=C3OCCO4)=CC=C2)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. van der Straat R, et al. 1,5-Disubstituted tetrazoles as PD-1/PD-L1 antagonists. RSC Medicinal Chemistry. 2024;15(4):1210-1215.

Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

Get Quote In-stock

Other size

Get Quote