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Cat. No.: HY-190134

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PD-L1 antagonist-2

PD-L1 antagonist-2 is a PD-L1 antagonist with an IC₅₀ of 408 nM. PD-L1 antagonist-2 is also a molecular glue. PD-L1 antagonist-2 induces PD-L1 dimerization/oligomerization and blocks the PD-1/PD-L1 interaction. PD-L1 antagonist-2 can be used for cancer research.

For research use only. We do not sell to patients.

CAS No.: 3123326-21-3
Formula: C₁₉H₂₁N₅
Molecular Weight:319.40

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

PD-L1 antagonist-2 Chemical Structure

CAS No.: 3123326-21-3

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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- In Vitro
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Biological Activity

Description

In Vitro

Immune Tolerance and ImmunosuppressionOthers

Immune Tolerance and Immunosuppression

PD-L1 antagonist-2 (compound 10f) (5-50 nM) antagonizes PD-1/PD-L1 binding with an HTRF IC₅₀ of 408 nM^[1].

Others

PD-L1 antagonist-2 induces hPD-L1 oligomerization in ¹H NMR titration^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 3123326-21-3
Molecular Weight 319.40
Formula C₁₉H₂₁N₅
SMILES

CCNCC1=NN=NN1/C=C/C2=C(C)C(C3=CC=CC=C3)=CC=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. van der Straat R, et al. 1,5-Disubstituted tetrazoles as PD-1/PD-L1 antagonists. RSC Med Chem. 2024 Feb 21;15(4):1210-1215.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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