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Cat. No.: HY-190257

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PDE3A/B-IN-1

PDE3A/B-IN-1 (Example 12) is a PDE3A/B molecular glue inhibitor. PDE3A/B-IN-1 inhibits tumor cell proliferation by inducing and stabilizing the formation of a complex between PDE3A/B and SLFN12 protein. PDE3A/B-IN-1 can be used for cancer research.

For research use only. We do not sell to patients.

CAS No.: 2275773-39-0
Formula: C₁₅H₁₃N₃O₃
Molecular Weight:283.28

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

PDE3A/B-IN-1 Chemical Structure

CAS No.: 2275773-39-0

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
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Chemical Information
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Description

IC₅₀ & Target

^[1]

PDE3A

PDE3B

All Phosphodiesterase (PDE) Isoforms :

In Vitro

Molecular glues are a class of small-molecule compounds that induce or stabilize novel protein-protein interactions (PPIs) between proteins that inherently lack natural affinity within cells. By remodeling the spatial topology of protein complexes, molecular glues achieve functional regulation of target proteins, structural stabilization, or specific degradation dependent on the ubiquitin-proteasome system.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Chemical Information

CAS No. 2275773-39-0
Molecular Weight 283.28
Formula C₁₅H₁₃N₃O₃
SMILES

CC1=C(C2=CNC(C=C2)=O)C=CC(C3=NNC(OC3)=O)=C1
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Manuel Ellermann, et al. PDE3A-SLFN12 complex inducers for cancer treatment. WO2019025562A1. WIPO. 2019-02-07.

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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PDE3A/B-IN-1

All Phosphodiesterase (PDE) Isoforms

Biological Activity

Description

IC50 & Target

In Vitro

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

PDE3A/B-IN-1 Related Classifications

HY-190257 Related Classifications

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