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Cat. No.: HY-190276

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PDE3A/B-IN-4

PDE3A/B-IN-4 is a PDE3A and PDE3B inhibitor with IC₅₀ values of 65 nM and 180 nM, respectively. PDE3A/B-IN-4 is also a molecular glue. PDE3A/B-IN-4 can be used in research related to cervical cancer.

For research use only. We do not sell to patients.

CAS No.: 2275775-70-5
Formula: C₁₆H₁₇F₃N₄O₃
Molecular Weight:370.33

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

PDE3A/B-IN-4 Chemical Structure

CAS No.: 2275775-70-5

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
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Biological Activity

Description

IC₅₀ & Target

^[1]

PDE3A

65 nM (IC₅₀)

PDE3B

180 nM (IC₅₀)

All Phosphodiesterase (PDE) Isoforms :

In Vitro

Anti-cancerOthers

Anti-cancer

PDE3A/B-IN-4 (Example 247) inhibits the proliferation of Hela cells with an IC₅₀ of 10 nM^[1].

Others

PDE3A/B-IN-4 (Example 247) inhibits the enzymatic activity of PDE3A and PDE3B in a cell-free system, with IC₅₀ values of 65 nM and 180 nM, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2275775-70-5
Molecular Weight 370.33
Formula C₁₆H₁₇F₃N₄O₃
SMILES

O=C1CC[C@H](CNC2=C(C(F)(F)F)C=C(C3=NNC(OC3)=O)C=C2)CN1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Ellermann M, et al. Bayer Aktiengesellschaft, Bayer Pharma Aktiengesellschaft, Broad Institute Inc, Dana-Farber Cancer Institute Inc. Dihydrooxadiazinones. WO 2019/025562 A1. Published 2019 Feb 07.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
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- In Vitro
Chemical Information
Purity & Documentation
References

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PDE3A/B-IN-4

All Phosphodiesterase (PDE) Isoforms

Biological Activity

Description

IC50 & Target

In Vitro

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

PDE3A/B-IN-4 Related Classifications

HY-190276 Related Classifications

Bioz

Keywords

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