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Cat. No.: HY-184945

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PDK ligand-1

PDK ligand-1 (Compound 16) is a target protein ligand that serves as an HsClpP recruitment module for constructing mitochondrially targeted pan-PDK degraders. PDK ligand-1 can be used for the synthesis of Pan-PDK degrader-1 (HY-184943).

For research use only. We do not sell to patients.

CAS No.: 252016-13-0
Formula: C₁₇H₁₃ClF₃NO₆S
Molecular Weight:451.80

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

PDK ligand-1 Chemical Structure

CAS No.: 252016-13-0

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

IC₅₀ & Target

PDK2

PDK3

PDK4

In Vitro

Ligands of target proteins cause compounds to bind to and degrade the target proteins.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 252016-13-0
Molecular Weight 451.80
Formula C₁₇H₁₃ClF₃NO₆S
SMILES

O=C(C1=CC=C(C=C1)S(=O)(C2=CC=C(C(Cl)=C2)NC([C@@](O)(C(F)(F)F)C)=O)=O)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Yang Y, et al. HsClpP-Engaging Selective Mitochondrial Pan-PDK Degraders for Cancer Therapy. Journal of medicinal chemistry. 2026 Jul 02. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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100 mg

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