Perfluorodecalin
Based on 1 Customer Validation
Perfluorodecalin liquids are largrly used in vitreoretinal surgery. Perfluorodecalin with tamponade lasting more than two days is detrimental to the retina in the case of rabbit. Perfluorodecalin can be used for the research of giant retinal tears. Perfluorodecalin is a non-toxic, non-flammable, thermally stable, non-bio-accumulating O2-carrier and used as artificial blood. Perfluorodecalin enhances bone regeneration and cell viability.
For research use only. We do not sell to patients.
- Purity : 98.0%
- CAS No.: 306-94-5
- Formula: C10F18
- Molecular Weight:462.08
-
Storage:Pure form -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
-
Solvent & Solubility
- Protocols
- Purity & Documentation
- References
-
Help & FAQs
-
HY-13631
ExatecanTopoisomerase I Inhibitor -
HY-109540
PerfluorohexaneHIFU Enhancer -
HY-108298R
Perfluorodecalin (Standard)Reference Standard -
HY-21190
Perfluorobutylsulfonyl fluorideIntermediate -
HY-Y0680
3-Chloro-4-fluoroanilineBiochemical Reagent -
HY-W007410
2,4-DifluorobenzaldehydeDrug Intermediate -
HY-W015477
2-Chloro-6-fluorobenzaldehydeBiochemical Reagent -
HY-21191
Perfluorobutanesulfonic acidBiochemical Assay Reagents -
HY-W002068
2,4-Difluorobenzoic acidDifluorinated Aromatic Carboxylic Acid -
HY-W008598
2-Bromo-4'-fluoroacetophenoneDNA Cleavage Inducer -
HY-W002172
2-Amino-5-chloro-2'-fluorobenzophenoneMidazolam Precursor -
HY-W015472
3,4-DifluoronitrobenzeneDrug Intermediate
Biological Activity
Description
In Vitro
Perfluorodecalin prolongs the cells survival in anaerobic environment, enhances the radiopacity, injectability, cohesion of bone cements and the bone regeneration[4]. Perfluorodecalin (10% v/v) ameliorates hypoxia and increases cell viability in transplantation of encapsulated islets[5].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:Albino rabbits[2]
-
Dosage:1.1-1.5 ml for each eye
-
Administration:injection into vitreous cavity
-
Result:Induced appearance of foam cells, preretinal membranes, and the interface necrosis.
Chemical Information
-
CAS No. 306-94-5
-
Appearance Liquid (Density: 1.9456 g/cm3)
-
Molecular Weight 462.08
-
Formula C10F18
-
Color Colorless to light yellow
-
SMILES
FC12C(F)(F)C(F)(F)C(F)(F)C(F)(F)C1(F)C(F)(F)C(F)(F)C(F)(F)C2(F)F
-
Synonyms
PP 5; Perfluorodecahydronaphthalene
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Pure form -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
In Vitro:
DMSO : 66.67 mg/mL (144.28 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 5 mg/mL (10.82 mM); Clear solution
This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 5 mg/mL (10.82 mM); Clear solution
This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
-
-
-
-
Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
-
%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
-
%+
-
+%Tween-80 + +
-
%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
-
Data Sheet (290 KB)
-
SDS (466 KB)
- English - EN (466 KB)
- Français - FR (466 KB)
- Deutsch - DE (466 KB)
- Norwegian - NO (466 KB)
- Español - ES (466 KB)
- Swedish - SV (466 KB)
- Italian - IT (466 KB)
- Korean - KR (466 KB)
- Portuguese - PT (466 KB)
-
Handling Instructions (2659 KB)
References
[1]. Orzalesi N, et al. Experimental short-term tolerance to perfluorodecalin in the rabbit eye: a histopathological study. Curr Eye Res. 1998;17(8):828-835. [Content Brief]
[2]. Bourke RD, et al. Experimental long-term vitreous replacement with purified and nonpurified perfluorodecalin. Am J Ophthalmol. 1994;118(3):403-404. [Content Brief]
[3]. Spahn DR. Blood substitutes. Artificial oxygen carriers: perfluorocarbon emulsions. Crit Care. 1999;3(5):R93-7. [Content Brief]
[4]. Tamimi F, et al., Perfluorodecalin and bone regeneration. Eur Cell Mater. 2013 Jan 2;25:22-36. [Content Brief]
[5]. Rodriguez-Brotons A, et al., Comparison of Perfluorodecalin and HEMOXCell as Oxygen Carriers for Islet Oxygenation in an In Vitro Model of Encapsulation. Tissue Eng Part A. 2016 Dec;22(23-24):1327-1336. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.1641 mL | 10.8206 mL | 21.6413 mL | 54.1032 mL |
| 5 mM | 0.4328 mL | 2.1641 mL | 4.3283 mL | 10.8206 mL | |
| 10 mM | 0.2164 mL | 1.0821 mL | 2.1641 mL | 5.4103 mL | |
| 15 mM | 0.1443 mL | 0.7214 mL | 1.4428 mL | 3.6069 mL | |
| 20 mM | 0.1082 mL | 0.5410 mL | 1.0821 mL | 2.7052 mL | |
| 25 mM | 0.0866 mL | 0.4328 mL | 0.8657 mL | 2.1641 mL | |
| 30 mM | 0.0721 mL | 0.3607 mL | 0.7214 mL | 1.8034 mL | |
| 40 mM | 0.0541 mL | 0.2705 mL | 0.5410 mL | 1.3526 mL | |
| 50 mM | 0.0433 mL | 0.2164 mL | 0.4328 mL | 1.0821 mL | |
| 60 mM | 0.0361 mL | 0.1803 mL | 0.3607 mL | 0.9017 mL | |
| 80 mM | 0.0271 mL | 0.1353 mL | 0.2705 mL | 0.6763 mL | |
| 100 mM | 0.0216 mL | 0.1082 mL | 0.2164 mL | 0.5410 mL |
Perfluorodecalin Related Classifications
HY-108298 Related Classifications
Powered by Bioz