PIK-124
Based on 1 Customer Validation
PIK-124 is a thiazolidinone-based PI3Kγ-biased PI3K inhibitor, with an IC50 of 3 nM against PI3Kγ. PIK-124 exhibits cross-reactivity with PI3Kα (IC50 = 23 nM), PI3Kδ (IC50 = 340 nM), PI3KC2α (IC50 = 140 nM) and PI3KC2β (IC50 = 370 nM). PIK-124 is applicable to breast cancer-related research.
For research use only. We do not sell to patients.
- Purity : 98.44%
- CAS No.: 711025-68-2
- Formula: C19H12ClFN2O3S2
- Molecular Weight:434.88
-
Storage:
4°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
-
Solvent & Solubility
- Protocols
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
Description
IC50 & Target
[1]|
PI3Kγ 3 nM (IC50) |
PI3Kα 23 nM (IC50) |
PI3Kδ 340 nM (IC50) |
PI3KC2α 140 nM (IC50) |
PI3KC2β 370 nM (IC50) |
In Vitro
PIK-124 shows weak inhibitory effect on p-Akt in PTEN-WT cells, but effectively inhibits PI3Kγ-enriched systems[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS No. 711025-68-2
-
Appearance Solid
-
Molecular Weight 434.88
-
Formula C19H12ClFN2O3S2
-
Color Light yellow to yellow
-
SMILES
O=C1NC(=S)SC1=CC2=CC=C3OCC(=O)N(C3=C2)CC4=CC=C(F)C(Cl)=C4
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
4°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
Solvent & Solubility
In Vitro:
DMSO : 50 mg/mL (114.97 mM; Need warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
-
Data Sheet (276 KB)
-
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
-
Handling Instructions (2659 KB)
References
[1]. Venable JD, et al. Phosphoinositide 3-kinase gamma (PI3Kgamma) inhibitors for the treatment of inflammation and autoimmune disease. Recent Pat Inflamm Allergy Drug Discov. 2010;4(1):1-15. [Content Brief]
[2].
Torbett NE, et al. A chemical screen in diverse breast cancer cell lines reveals genetic enhancers and suppressors of sensitivity to PI3K isoform-selective inhibition. Biochem J. 2008 Oct 1;415(1):97-110.
[Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.2995 mL | 11.4974 mL | 22.9948 mL | 57.4871 mL |
| 5 mM | 0.4599 mL | 2.2995 mL | 4.5990 mL | 11.4974 mL | |
| 10 mM | 0.2299 mL | 1.1497 mL | 2.2995 mL | 5.7487 mL | |
| 15 mM | 0.1533 mL | 0.7665 mL | 1.5330 mL | 3.8325 mL | |
| 20 mM | 0.1150 mL | 0.5749 mL | 1.1497 mL | 2.8744 mL | |
| 25 mM | 0.0920 mL | 0.4599 mL | 0.9198 mL | 2.2995 mL | |
| 30 mM | 0.0766 mL | 0.3832 mL | 0.7665 mL | 1.9162 mL | |
| 40 mM | 0.0575 mL | 0.2874 mL | 0.5749 mL | 1.4372 mL | |
| 50 mM | 0.0460 mL | 0.2299 mL | 0.4599 mL | 1.1497 mL | |
| 60 mM | 0.0383 mL | 0.1916 mL | 0.3832 mL | 0.9581 mL | |
| 80 mM | 0.0287 mL | 0.1437 mL | 0.2874 mL | 0.7186 mL | |
| 100 mM | 0.0230 mL | 0.1150 mL | 0.2299 mL | 0.5749 mL |
PIK-124 Related Classifications
HY-118903 Related Classifications
Powered by Bioz